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Kościuszko et al. Hepatoma Res 2021;7:51  https://dx.doi.org/10.20517/2394-5079.2021.17  Page 7 of 16

               Table 3. A summary of the types of preoperative imaging studies used, as well as the software and types of technology implemented
               in the study
                Ref.         Preoperativestudy used  Software used                       What was performed
                        [46]
                Plumley et al.  CT              No data                                  3D reconstruction
                      [47]
                Fuchs et al.  CT                MeVis service                            3D reconstruction
                      [48]
                Dong et al.  CT                 4D Recon Card Wizard (Siemens)           3D reconstruction
                Fuchs et al. [49]  CT           MeVis service                            3D reconstruction
                        [50]
                Souzaki et al.  CT/MRI          Virtual Place 300, AZE Co (Now AZE Virtual Place, Cannon)  Augmented reality
                Souzaki et al. [51]  CT         ZedView, 3D Doctor, FreeForm, CATIA      3D printing
                    [52]
                Su et al.    CT                 Higemi                                   3D reconstruction
                Soejima et al. [53]  CT         Free Form, K’s Design Lab                3D printing
                    [54]
                Su et al.    CT                 Hisense CAS system                       3D reconstruction
                Warmann et al. [55]  CT/MRI     MeVis service                            3D reconstruction
                       [57]
                Zhang et al.  CT                Hisense CAS system                       3D reconstruction
                Janek et al. [58]  CT           MeVis service                            3D reconstruction
                      [59]
                Zhao et al.  CT                 Hisense CAS system                       3D reconstruction
                       [60]
                Wang et al.  CT/MRI             IQQALiver; EDDA Technology               3D printing
                Esaki et al. [61]  CT           U-Net and three-dimensional (3D) workstations (3DWS)  Deep learning
                     [63]
                Ishii et al.  CT                Synapse Vincent (Fujifilm)               3D printing

               Table 4. Outcome measures
                Ref.        Measured outcomes
                Plumley et al. [46]  Recurrences, kidney function, changing the operation plan
                      [47]
                Fuchs et al.  The margin of resection, intraoperative complications, portal venous thrombosis
                Dong et al. [48]  Operation time, blood loss, mortality, surgeons subjective opinion
                      [49]
                Fuchs et al.  The margin of resection, intraoperative complications, portal venous thrombosis
                Souzaki et al. [50]  Operation time, reoperations, mortality, intra- and postoperative complications
                        [51]
                Souzaki et al.  Recurrence, the margin of resection
                Su et al. [52]  Operation time, blood loss, blood transfusion, mortality
                        [53]
                Soejima et al.  Operation time, blood loss, blood transfusion, mortality, postoperative complications
                    [54]
                Su et al.   Operation time, blood loss, blood transfusion, mortality, postoperative complications, recurrence, RSLVR
                         [55]
                Warmann et al.  Mortality, the margin of resection, changing operation plan
                       [57]
                Zhang et al.  Operation time, blood loss, intra- and postoperative complications, postoperative stay, the margin of resection, recurrence
                Janek et al. [58]  Blood loss, blood transfusion, recurrence, bilirubin levels, the volume of post-resection liver residue
                      [59]
                Zhao et al.  Operation time, blood loss, blood transfusion
                Wang et al. [60]  Operation time, blood loss, mortality, intra- and postoperative complications, inpatient stay, cost
                      [61]
                Esaki et al.  Liver and spleen volume measurement
                Ishii et al.  [63]  Operation time, blood loss, intraoperative complications

                                 [49]
               In 2010, Fuchs et al.  proposed an approach to the planning of surgical treatment of liver vascular
               malformations in children. This approach incorporated MeVis LiverAnalyzer and MeVis LiverExplorer
               (Mevis, Bremen, Germany). Twelve children were diagnosed with hepatic vascular malformations. The
               patients were assessed for Rex shunt procedure and other interventions. Liver segmentations were
               performed using the livewire segmentation technique. This semiautomatic technique needs user input to set
               anchors around the region of interest. The smallest “cost path” is then drawn from the anchor to the pixel
               where the pointer is. The path is changed whenever the user moves the pointer.
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