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Page 6 of 16 Brunsing et al. Hepatoma Res 2020;6:59 I http://dx.doi.org/10.20517/2394-5079.2020.50

Comments All lesions less than 2cm NC-AMRI was DWI only NC-AMRI was DWI only: 17 HCC All scans at 1.5 Tesla; 19 HCC Used coronal T2 as localizing sequence 27 HCC

Spec. 0.78 0.82 0.86 0.98 0.88 0.66 0.88 0.93 0.96 NR 0.99

Sens. 0.92 0.84 0.86 0.83 0.78 0.68 0.92 0.83 0.80 0.85 0.91

Analysis Per- patient Per- patient Per- patient Per- patient Per- lesion* Per- lesion* Per- patient Per- patient Per- patient Per- lesion* Per- patient

Sample size 128 pts 247 pts 44 pts 192 pts 37 pts* 50 pts* 100 pts 298 pts 174 pts 79 pts* 141 pts

Reference standard Path or FU Path, cMRI, FU cMRI Path, cMRI, CT Explant Explant Path, cMRI, FU cMRI or FU Path or cMRI Path of cMRI cMRI or CT

Liver disease Mixed** Mixed** Cirrhosis Mixed** Mixed** Cirrhosis Cirrhosis Cirrhosis or HBV Mixed** Cirrhosis or HBV Cirrhosis or HBV

Intent of source imaging Diagnosis Diagnosis Diagnosis Surveillance Surveillance Diagnosis* Diagnosis Surveillance Mixed*** Surveillance Surveillance *See comments; **“Mixed” under “Liver Disease” refers to a cohort or population with mixed etiologies of liver disease which is not easily summarized; ***“Mixed” under “Intent of source imaging” indicates that imaging included in the study could have been done either for the purpose of diagno

Design Retros Retros Retros Prosp Retros Retros Retros Retros Retros Retros Retros MRI; NR: not reported; Path: histopathology; Prosp: prospective study; pts: patients; Retros: retrospective study; Sens: sensitivity; Spec: specificity; USA: United States

Target Malignancy* HCC HCC HCC HCC HCC HCC HCC HCC HCC HCC

Country Korea Korea Australia Australia USA USA USA USA USA USA USA studies to-date evaluating the performance of AMRI interpreted prospectively in the clinical setting.

Approach NC-AMRI NC-AMRI NC-AMRI NC-AMRI* NC-AMRI* Dyn-AMRI Dyn-AMRI HBP-AMRI HBP-AMRI HBP-AMRI HBP-AMRI

Context of image interpretation Simulation Simulation Simulation Clinical practice Simulation Simulation Simulation Simulation Simulation Simulation Clinical practice

Table 2. AMRI studies to date Year Author 2014 Kim et al. [23] 2018 Han et al. [24] 2019 Chan et al. [25] 2016 Sutherland et al. [34] 2018 McNamara [36] 2006 Hecht et al. [35] 2020 Khatri et al. [27] 2015 Marks et al. [28] 2017 Besa et al. [29] 2018 Tillman et al. [30] 2019 Brunsing et al. [31] Summary statement