Page 82 - Read Online
P. 82
Page 6 of 13 Farrell et al. Hepatoma Res 2020;6:18 I http://dx.doi.org/10.20517/2394-5079.2019.019
Median follow up of 13 months so longer term survival results may not be truly reflective of the general population Retrospective case series with selection bias for patients who underwent liver biopsy ALT is not always an accurate diagnostic marker for NAFLD and this method may be underestimate prevalence in both NAFLD and control No clear definition of NAFLD used Retrospective design and cohort derived from a tertiary referral centre wh
53.8% 56.6% 80% group N/A 63%
46.2% of NAFLD associated HCC were non-cirrhotic compared to 2.8% in those with HCV 73.1% of NAFLD-related HCC patients have diabetes mellitus compared with only 24.9% of HCV-related HCC patients NAFLD HCC detected at later stage, had larger volume and more infiltrative pattern compared to HCV-related HCC Non-significant survival difference NAFLD 28.5 months vs. 35 months in HCV 43.4% of NAFLD-related HCC occurred with a non-cirrhotic liver N
NAFLD if all other known aetiologies of liver disease could be ruled out and if consistent present or past histological or ultra sonographic features of fatty liver and alcohol intake < 30 g/day Histologically 2 or more elevated ALT values (> 40 IU/mL for men and > 31 IU/ mL for women) in the outpatient setting in the absence of other causes of liver disease or any ICD codes for alcohol use Medical chart review NAFLD defined by no other caus
296,707 30
145 83 272 225
Multicentre observational prospective cohort of patients with NAFLD- related HCC Retrospective analysis of patients diagnosed with HCC and NAFLD at the Cleveland Clinic between 2003 and 2012 Prospective longitudinal cohort of NAFLD patients with matched controls Multicentre prospective cohort of newly diagnosed HCC between 2012 and 2013 Single centre retrospective cohort study of all HCC patients at Karolinska Un
Italy USA USA Australia Sweden
Piscaglia et al. [49] Mohamad et al. [48] Kanwal et al. [32] Hong et al. [42] Bengtsson et al. [52]
