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Farrell et al. Hepatoma Res 2020;6:18 I http://dx.doi.org/10.20517/2394-5079.2019.019 Page 5 of 13
Used a modified diagnostic criterion for NASH. Did not present proportion of cirrhotic patients. Transplant patients tend to have high adherence and engagement with medical care, which may account for the older and heavier patients undergoing transplant with NASH Retrospective single centre study in a region which high rates of obesity and diabetes Multiple centres in different regions without a clear definition of NAFLD Coding information
N/A 77.2% N/A used N/A 58.3% N/A
HCC (8.3% in 2002 vs. 10.3% in 2007 Documented diagnosis of NASH or NASH was 2nd leading cause of OLT for vs. 13.5% in 2012) behind HCV but the most rapidly growing indication (4× increase in NASH, 2× increase in HCV) Non-NASH-related HCC patients were more likely to be men (79.2% vs. 70.6%) and were younger at time of OLT (57.2 ± 7.6 vs. 59.3 ± 7.3) NASH-related patients had higher BMI (33.6 ± 4.3 vs. 27.3 ± 4.9) and higher rates of diabetes
obese patients with cryptogenic/ unknown aetiology of liver disease Evidence of a fatty liver on biopsy or imaging, with an otherwise negative liver screen, drinking < 21 or < 14 units of alcohol per week respectively for at least 5 years prior to their first presentation with liver disease Medical chart review ICD codes NAFLD also defined by clinical diagnosis (cryptogenic cirrhosis, obese-diabetics with cryptogenic liver disease) Histol
10,061 632 18,301 (Asia 67% of patients, Europe 20% and North America 13%) 4929 1500 44
Retrospective cohort study of OLT recipients on organ registry for HCC in US from 2002 to 2012. Retrospective longitudinal cohort of consecutive HCC cases between 2000 and 2010 The BRIDGE study. Observational longitudinal cohort in 42 countries between 2005 and 2012 Longitudinal cohort study using SEER registries to identify patients with HCC between 2004 and 2009 Retrospective cohort analysis of patients with HCC
USA UK Multi- regional USA USA USA
Wong et al. [38] Dyson et al. [34] Park et al. [7] Younossi et al. [8] Mittal et al. [37] Perumpail et al. [71]
