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Qu et al. Hepatoma Res 2020;6:38 I http://dx.doi.org/10.20517/2394-5079.2020.12 Page 5 of 7

targeting cancer vaccines and checkpoint inhibitors will improve the efficacy of immunotherapy. Murine
models have proven the effect of HCC cancer vaccines in compensating for anti-PD-1 by targeting cDC1s.
However, clinical trials of such cancer vaccine are still required. It is also necessary to understand how
cDC1s regulate anti-tumor immunity.

DECLARATIONS
Authors’ contributions
Manuscript draft and finalization: Qu C
Participated in drafting of the manuscript: Chen K, Cheng SY

Availability of data and materials
Not applicable.

Financial support and sponsorship
This work was supported by the Natural Science Foundation of China (No. 81571620) and the Chinese
Academy of Medical Sciences Innovative Medicine (No. 2016-I2M-1-007).

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2020.

REFERENCES
1. Chen DS, Mellman I. Elements of cancer immunity and the cancer-immune set point. Nature 2017;541:321-30.
2. Friedrich MJ. Immunotherapy 2.0: improving the response to checkpoint inhibitors. JAMA 2019;321:131-3.
3. Shankaran V, Ikeda H, Bruce AT, White JM, Swanson PE, et al. IFNgamma and lymphocytes prevent primary tumour development and
shape tumour immunogenicity. Nature 2001;410:1107-11.
4. van Dinther D, Stolk DA, van de Ven R, van Kooyk Y, de Gruijl TD, et al. Targeting C-type lectin receptors: a high-carbohydrate diet for
dendritic cells to improve cancer vaccines. J Leukoc Biol 2017;102:1017-34.
5. Romero P, Banchereau J, Bhardwaj N, Cockett M, Disis ML, et al. The Human Vaccines Project: A roadmap for cancer vaccine
development. Sci Transl Med 2016;8:334ps9.
6. Muller WA, Randolph GJ. Migration of leukocytes across endothelium and beyond: molecules involved in the transmigration and fate of
monocytes. J Leukoc Biol 1999;66:698-704.
7. Jakubzick C, Gautier EL, Gibbings SL, Sojka DK, Schlitzer A, et al. Minimal differentiation of classical monocytes as they survey
steady-state tissues and transport antigen to lymph nodes. Immunity 2013;39:599-610.
8. Yona S, Kim KW, Wolf Y, Mildner A, Varol D, et al. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages
under homeostasis. Immunity 2013;38:79-91.
9. Scott CL, Zheng F, De Baetselier P, Martens L, Saeys Y, et al. Bone marrow-derived monocytes give rise to self-renewing and fully
differentiated Kupffer cells. Nat Commun 2016;7:10321.
10. Ramachandran P, Dobie R, Wilson-Kanamori JR, Dora EF, Henderson BEP, et al. Resolving the fibrotic niche of human liver cirrhosis at
single-cell level. Nature 2019;575:512-8.
11. Naik SH, Sathe P, Park HY, Metcalf D, Proietto AI, et al. Development of plasmacytoid and conventional dendritic cell subtypes from
single precursor cells derived in vitro and in vivo. Nat Immunol 2007;8:1217-26.
12. Onai N, Obata-Onai A, Schmid MA, Ohteki T, Jarrossay D, et al. Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and
conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol 2007;8:1207-16.
13. Palomino-Segura M, Perez L, Farsakoglu Y, Virgilio T, Latino I, et al. Protection against influenza infection requires early recognition by