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Chávez-López et al. Hepatoma Res 2020;6:14 I http://dx.doi.org/10.20517/2394-5079.2019.023 Page 11 of 16

Figure 1. Ion channel-based therapy for HCC prevention and treatment. The expression of several ion channels is altered in liver disorders
leading to HCC, as well as in HCC. Because of the very relevant participation of ion channels in cellular processes leading to HCC,
targeting either the expression or activity of these proteins may lead to the prevention and treatment of liver diseases including HCC.
HCC: hepatocellular carcinoma; HCV: hepatitis C virus; HBV: hepatitis B virus; NAFLD: nonalcoholic fatty liver disease

CONCLUSION
Ion channels offer a plethora of opportunities for the prevention, diagnosis, and treatment of liver diseases
[Figure 1], as well as represent potential tools as HCC prognostic markers [Table 3]. This ion-channel-
based approach may help to reduce the mortality of this very poor prognosis disease.

DECLARATION
Authors’ contributions
Contributed to the conception and design of the review, wrote the paper and revised the final draft:
Chávez-López MG, Cruz-Díaz A, Tlapalcoyoa-Apanco KN, Pérez-Carreón JI, Camacho J

Availability of data and materials
Not applicable.

Financial support and sponsorship
None.