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Rastogi. Hepatoma Res 2020;6:47 I http://dx.doi.org/10.20517/2394-5079.2020.35 Page 13 of 17
are scarce. In the era of molecular targeted therapies, there is an urgent need to analyze the carcinogenetic
mechanisms and pathology based phenotypic correlates of specific molecular aberrations in HCCs
originating in non-cirrhotic livers.
DECLARATIONS
Acknowledgments
Prof. (Dr.) SK Sarin, Senior Professor (Dept. of Hepatology) & Director, Institute of Liver & Biliary
Sciences, Delhi, for constant guidance & support. Dr. Gayatri Ramakrishna, Additional Professor,
Department of Molecular & Cellular Medicine, for creating figure of molecular pathways.
Authors’ contributions
The author contributed solely to the article.
Availability of data and materials
Not applicable.
Financial support and sponsorship
None.
Conflicts of interest
The authors declared that there are no conflicts of interest.
Ethical approval and consent to participate
Not applicable.
Consent for publication
Not applicable.
Copyright
© The Author(s) 2020.
REFERENCES
1. Rastogi A. Changing role of histopathology in the diagnosis and management of hepatocellular carcinoma. World J Gastroenterol
2018;24:4000-13.
2. Gaddikeri S, McNeeley MF, Wang CL, Bhargava P, Dighe MK, et al. Hepatocellular carcinoma in the noncirrhotic liver. Am J Roentgenol
2014;203:W34-47.
3. El-Serag HB. Hepatocellular carcinoma. N Engl J Med 2011;365:1118-27.
4. Wörns MA, Bosslet T, Victor A, Koch S, Hoppe-Lotichius M, et al. Prognostic factors and outcomes of patients with hepatocellular
carcinoma in non-cirrhotic liver. Scand J Gastroenterol 2012;47:718-28.
5. Schütte K, Kipper M, Kahl S, Bornschein J, Götze T, et al. Clinical characteristics and time trends in etiology of hepatocellular cancer in
Germany. Digestion 2013;87:147-59.
6. Trevisani F, Frigerio M, Santi V, Grignaschi A, Bernardi M. Hepatocellular carcinoma in non-cirrhotic liver: a reappraisal. Dig Liver Dis
2010;42:341-7.
7. Zhang Y, Wang C, Xu H, Xiao P, Gao Y. Hepatocellular carcinoma in the noncirrhotic liver: a literature review. Eur J Gastroenterol
Hepatol 2019;31:743-8.
8. Schütte K, Schulz C, Poranzke J, Antweiler K, Bornschein J, et al. Characterization and prognosis of patients with hepatocellular
carcinoma (HCC) in the non-cirrhotic liver. BMC Gastroenterol 2014;14:117.
9. Lafitte M, Laurent V, Soyer P, Ayav A, Balaj C, et al. MDCT features of hepatocellular carcinoma (HCC) in non-cirrhotic liver. Diagn
Interv Imaging 2016;97:355-60.
10. Di Martino M, Saba L, Bosco S, Rossi M, Miles KA, et al. Hepatocellular carcinoma (HCC) in non-cirrhotic liver: clinical, radiological
and pathological findings. Eur Radiol 2014;24:1446-54.
11. Desai A, Sandhu S, Lai JP, Sandhu DS. Hepatocellular carcinoma in non-cirrhotic liver: a comprehensive review. World J Hepatol