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Matsushita et al. Hepatoma Res 2018;4:61 I http://dx.doi.org/10.20517/2394-5079.2018.81 Page 11 of 17

A

B
MTS Assay (Cell confluency was 80% at time of drug treatment)

HLE cells HLF cells
1.4 2.0

1 μg/well 1.8 1 μg/well
1.2
1.6
2 μg/well 2 μg/well
1.0 1.4
1.2
0.8
1.0
0.6
0.8
0.6
0.4
0.4
0.2
0.2
0 0
Negative control
Blank (untreated) Positive control BK-645 BK-665 BK-696 BK-697 BK-698 BK-699 BK-670 Blank (untreated) Positive control BK-645 BK-665 BK-696 BK-697 BK-698 BK-699 BK-670
Negative control