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Page 8 of 10                                          Papaluca et al. Hepatoma Res 2018;4:64  I  http://dx.doi.org/10.20517/2394-5079.2018.53


               population level support the development and implementation of novel public health platforms, including
               within the prison system. Such prison-based HCV treatment programs will facilitate the engagement and
               treatment of PWIDs, a key role in promoting the achievement of the WHO elimination goals by 2030.

               Multiple barriers within the prison impede HCV management in prisons. Future studies should evaluate
               models of care that overcome these barriers. It will be important to evaluate the implementation of enhanced
               opt-out screening programs in all correctional facilities; the benefit of point of care diagnosis and referral
               on prison reception for reducing the time for diagnosis to treatment; and the benefit of peer-led prisoner
               education programs to promote uptake of screening and treatment. Historically HCV therapy for prisoners has
               been impeded by delays in transfer for specialist assessment, frequent prisoner transfer interrupting treatment
               and the need for frequent transfer to tertiary centres for monitoring and diagnostics. The development of
               jurisdiction-wide, comprehensive “in-reach” hepatitis treatment program could overcome these barriers and
               provide HCV care locally at each prison site, minimising the need for transfers.

               In conclusion, prisoner hepatitis treatment programs should be included in HCV elimination paradigms to
               maximise the TAsP effect. Novel treatment programs are needed to access and scale up treatment in these
               marginalised populations.


               DECLARATIONS
               Authors’ contributions
               Both authors contributed equally to the research and writing of the manuscript.


               Availability of data and materials
               Not applicable.


               Financial support and sponsorship
               None.


               Conflicts of interest
               All authors declared that there are no conflicts of interest.

               Ethical approval and consent to participate
               Not applicable.

               Consent for publication
               Not applicable.

               Copyright
               © The Author(s) 2018.

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