Page 37 - Read Online

Lozano-Rosas et al. Hepatoma Res 2018;4:19 I http://dx.doi.org/10.20517/2394-5079.2018.48 Page 13 of 14

BC. Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell
growth. Cancer Res 2012;72:4138-49.
52. Barres R, Osler ME, Yan J, Rune A, Fritz T, Caidahl K, Krook A, Zierath JR. Non-CpG methylation of the PGC-1alpha promoter
through DNMT3B controls mitochondrial density. Cell Metab 2009;10:189-98.
53. Scarpulla RC. Nuclear control of respiratory gene expression in mammalian cells. J Cell Biochem 2006;97:673-83.
54. Hanaoka S, Ishida K, Tanaka S, Sakamoto S, Okuda K, Sanoh S, Ohta S, Kotake Y. Tributyltin induces epigenetic changes and
decreases the expression of nuclear respiratory factor-1. Metallomics 2018;10:337-45.
55. Ozawa T. Mitochondrial DNA mutations and age. Ann N Y Acad Sci 1998;854:128-54.
56. Smiraglia DJ, Kulawiec M, Bistulfi GL, Gupta SG, Singh KK. A novel role for mitochondria in regulating epigenetic modification in the
nucleus. Cancer Biol Ther 2008;7:1182-90.
57. Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.
Annu Rev Genet 2005;39:359-407.
58. Chen C, Chen Y, Guan MX. A peep into mitochondrial disorder: multifaceted from mitochondrial DNA mutations to nuclear gene
modulation. Protein Cell 2015;6:862-70.
59. Cassim S, Raymond VA, Dehbidi-Assadzadeh L, Lapierre P, Bilodeau M. Metabolic reprogramming enables hepatocarcinoma cells to
efficiently adapt and survive to a nutrient-restricted microenvironment. Cell Cycle 2018; doi: 10.1080/15384101.2018.1460023.
60. Comerford SA, Huang Z, Du X, Wang Y, Cai L, Witkiewicz AK, Walters H, Tantawy MN, Fu A, Manning HC, Horton JD, Hammer RE,
McKnight SL, Tu BP. Acetate dependence of tumors. Cell 2014;159:1591-602.
61. Mato JM, Lu SC. Role of S-adenosyl-L-methionine in liver health and injury. Hepatology 2007;45:1306-12.
62. Mato JM, Martinez-Chantar ML, Lu SC. S-adenosylmethionine metabolism and liver disease. Ann Hepatol 2013;12:183-9.
63. Tohme S, Yazdani HO, Liu Y, Loughran P, van der Windt DJ, Huang H, Simmons RL, Shiva S, Tai S, Tsung A. Hypoxia mediates
mitochondrial biogenesis in hepatocellular carcinoma to promote tumor growth through HMGB1 and TLR9 interaction. Hepatology
2017;66:182-97.
64. Zhang C, Li J, Huang T, Duan S, Dai D, Jiang D, Sui X, Li D, Chen Y, Ding F, Huang C, Chen G, Wang K. Meta-analysis of DNA
methylation biomarkers in hepatocellular carcinoma. Oncotarget 2016;7:81255-67.
65. Malik AN, Czajka A. Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction? Mitochondrion 2013;13:481-92.
66. Singh KK, Kulawiec M, Still I, Desouki MM, Geradts J, Matsui S. Inter-genomic cross talk between mitochondria and the nucleus plays
an important role in tumorigenesis. Gene 2005;354:140-6.
67. Ye C, Tao R, Cao Q, Zhu D, Wang Y, Wang J, Lu J, Chen E, Li L. Whole-genome DNA methylation and hydroxymethylation profiling
for HBV-related hepatocellular carcinoma. Int J Oncol 2016;49:589-602.
68. Wu YL, Wang D, Peng XE, Chen YL, Zheng DL, Chen WN, Lin X. Epigenetic silencing of NAD(P)H:quinone oxidoreductase 1 by
hepatitis B virus X protein increases mitochondrial injury and cellular susceptibility to oxidative stress in hepatoma cells. Free Radic
Biol Med 2013;65:632-44.
69. Mizukami S, Yafune A, Watanabe Y, Nakajima K, Jin M, Yoshida T, Shibutani M. Identification of epigenetically downregulated
Tmem70 and Ube2e2 in rat liver after 28-day treatment with hepatocarcinogenic thioacetamide showing gene product downregulation
in hepatocellular preneoplastic and neoplastic lesions produced by tumor promotion. Toxicol Lett 2017;266:13-22.
70. Hejzlarova K, Tesarova M, Vrbacka-Cizkova A, Vrbacky M, Hartmannova H, Kaplanova V, Noskova L, Kratochvilova H, Buzkova
J, Havlickova V, Zeman J, Kmoch S, Houstek J. Expression and processing of the TMEM70 protein. Biochim Biophys Acta
2011;1807:144-9.
71. Havlickova Karbanova V, Cizkova Vrbacka A, Hejzlarova K, Nuskova H, Stranecky V, Potocka A, Kmoch S, Houstek J. Compensatory
upregulation of respiratory chain complexes III and IV in isolated deficiency of ATP synthase due to TMEM70 mutation. Biochim
Biophys Acta 2012;1817:1037-43.
72. Shah ZH, Migliosi V, Miller SC, Wang A, Friedman TB, Jacobs HT. Chromosomal locations of three human nuclear genes (RPSM12,
TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus. Genomics 1998;48:384-8.
73. Jin D, Li R, Mao D, Luo N, Wang Y, Chen S, Zhang S. Mitochondria-localized glutamic acid-rich protein (MGARP) gene transcription
is regulated by Sp1. PLoS One 2012;7:e50053.
74. Shahbazian MD, Grunstein M. Functions of site-specific histone acetylation and deacetylation. Annu Rev Biochem 2007;76:75-100.
75. Bannister AJ, Schneider R, Kouzarides T. Histone methylation: dynamic or static? Cell 2002;109:801-6.
76. Minocherhomji S, Tollefsbol TO, Singh KK. Mitochondrial regulation of epigenetics and its role in human diseases. Epigenetics
2012;7:326-34.
77. Hayami S, Kelly JD, Cho HS, Yoshimatsu M, Unoki M, Tsunoda T, Field HI, Neal DE, Yamaue H, Ponder BA, Nakamura Y, Hamamoto
R. Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. Int J Cancer
2011;128:574-86.
78. Sakamoto A, Hino S, Nagaoka K, Anan K, Takase R, Matsumori H, Ojima H, Kanai Y, Arita K, Nakao M. Lysine demethylase LSD1
coordinates glycolytic and mitochondrial metabolism in hepatocellular carcinoma cells. Cancer Res 2015;75:1445-56.
79. Gailhouste L, Gomez-Santos L, Ochiya T. Potential applications of miRNAs as diagnostic and prognostic markers in liver cancer. Front
Biosci (Landmark Ed) 2013;18:199-223.
80. Burchard J, Zhang C, Liu AM, Poon RT, Lee NP, Wong KF, Sham PC, Lam BY, Ferguson MD, Tokiwa G, Smith R, Leeson B, Beard
R, Lamb JR, Lim L, Mao M, Dai H, Luk JM. microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular
carcinoma. Mol Syst Biol 2010;6:402.