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DECLARATIONS
Authors’ contributions
All authors contributed actively in the search of useful information and participated in the writing of this
review.

Availability of data and materials
Not applicable.

Financial support and sponsorship
This work was supported by Consejo Nacional de Ciencia y Tecnología (240315) and Dirección General de
Asuntos del Personal Académico-Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica
(DGAPA-PAPIIT) (IN208915).

Conflicts of interest
All authors declare that they have no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2018.

REFERENCES
1. Cardin R, Piciocchi M, Bortolami M, Kotsafti A, Barzon L, Lavezzo E, Sinigaglia A, Rodriguez-Castro KI, Rugge M, Farinati F.
Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma: an intricate pathway. World J Gastroenterol
2014;20:3078-86.
2. Tu T, Budzinska MA, Maczurek AE, Cheng R, Di Bartolomeo A, Warner FJ, McCaughan GW, McLennan SV, Shackel NA. Novel
aspects of the liver microenvironment in hepatocellular carcinoma pathogenesis and development. Int J Mol Sci 2014;15:9422-58.
3. Manev H, Dzitoyeva S. Progress in mitochondrial epigenetics. Biomol Concepts 2013;4:381-9.
4. Bellizzi D, D’Aquila P, Giordano M, Montesanto A, Passarino G. Global DNA methylation levels are modulated by mitochondrial DNA
variants. Epigenomics 2012;4:17-27.
5. Barbosa IA, Machado NG, Skildum AJ, Scott PM, Oliveira PJ. Mitochondrial remodeling in cancer metabolism and survival: potential
for new therapies. Biochim Biophys Acta 2012;1826:238-54.
6. Hernandez-Munoz R, Chagoya de Sanchez V. In vivo correlation between liver and blood energy status as evidenced by chronic
treatment of carbon tetrachloride and adenosine to rats. Can J Physiol Pharmacol 1994;72:1252-6.
7. Hernandez-Munoz R, Glender W, Diaz-Munoz M, Suarez J, Lozano J, Chagoya de Sanchez V. Alterations of ATP levels and of energy
parameters in the blood of alcoholic and nonalcoholic patients with liver damage. Alcohol Clin Exp Res 1991;15:500-3.
8. Chavez E, Lozano-Rosas MG, Dominguez-Lopez M, Velasco-Loyden G, Rodriguez-Aguilera JR, Jose-Nunez C, Tuena de Gomez-
Puyou M, Chagoya de Sanchez V. Functional, metabolic, and dynamic mitochondrial changes in the rat cirrhosis-hepatocellular
carcinoma model and the protective effect of IFC-305. J Pharmacol Exp Ther 2017;361:292-302.
9. Warburg O. On respiratory impairment in cancer cells. Science 1956;124:269-70.
10. Singh KK, Russell J, Sigala B, Zhang Y, Williams J, Keshav KF. Mitochondrial DNA determines the cellular response to cancer
therapeutic agents. Oncogene 1999;18:6641-6.
11. Modica-Napolitano JS, Kulawiec M, Singh KK. Mitochondria and human cancer. Curr Mol Med 2007;7:121-31.
12. Modica-Napolitano JS, Singh KK. Mitochondrial dysfunction in cancer. Mitochondrion 2004;4:755-62.
13. Penta JS, Johnson FM, Wachsman JT, Copeland WC. Mitochondrial DNA in human malignancy. Mutat Res 2001;488:119-33.
14. Graier WF, Frieden M, Malli R. Mitochondria and Ca(2+) signaling: old guests, new functions. Pflugers Arch 2007;455:375-96.
15. Kasahara A, Scorrano L. Mitochondria: from cell death executioners to regulators of cell differentiation. Trends Cell Biol 2014;24:761-70.
16. Mposhi A, Van der Wijst MG, Faber KN, Rots MG. Regulation of mitochondrial gene expression, the epigenetic enigma. Front Biosci
(Landmark Ed) 2017;22:1099-113.