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Wang et al. Hepatoma Res 2018;4:14 I http://dx.doi.org/10.20517/2394-5079.2018.16 Page 7 of 10

in improving the long-term effect of HCC. Molecular cloning detection is an important theoretical and
technical support to break this bottleneck. Therefore, strengthening the study of clonal origin of HCC and
establishing a scientific and precise molecular cloning detection technology will be an important task in
the field of HCC pathology. The innovation of molecular cloning technology provides guidance for the
individualized treatment strategy of RHCC and MHCC. The overall view is that the IM type HCC has a
more malignant biological behavior, and poorer clinical prognosis than the MO type HCC, no matter RHCC
or MHCC.

The molecular pathological technical standards for evaluating the clonal origin of HCC have not yet been
unified. Microsatellite LOH detection is currently the most widely used method in clinical practice. We
should explore the method to unite high sensitivity and specificity, low cost, convenient and quick to serve
the clinical practice better in future.

DECLARATIONS
Authors’ contributions
Reviewed the literature and wrote the manuscript: Wang H, Cong WM

Financial support and sponsorship
None.

Conflicts of interest
There are no conflicts of interest.

Patient consent
Not applicable.

Ethics approval
Not applicable.

Copyright
© The Author(s) 2018.

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