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Yang et al. Chem Synth 2023;3:7 https://dx.doi.org/10.20517/cs.2022.38 Page 3 of 54
Figure 1. Typical biologically active spirolactones containing spiropropyllactones, spirobutyrolactones and spirovalerolactones.
Scheme 1. Lactone-related frameworks as building blocks for the construction of chiral spirolactones.
Benzolactone-derived olefins as 2C synthons
The spiro benzolactone motif is a privileged synthetic moiety that can be found in many natural products
with a wide range of biological activities [Figure 1]. For example, Rosmadial [21-23] , isolated from aerial parts
