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Yamamoto. Chem Synth 2022;2:14 https://dx.doi.org/10.20517/cs.2022.12 Page 5 of 6

Figure 7. Flow peptide synthesis.

Figure 8. Non-racemization process using silicone reagent.

Reduction of process mass intensity
Because the reactants are very inexpensive and have low molecular weight, the number of steps is small, and
high concentration reactions are possible, the process mass intensity is exceedingly small.

Henceforth, we can confirm the social implementation of this new synthesis method through joint research
with companies and simultaneously make daily efforts to make the method more elegant. In particular, we
have started to develop a catalytic reaction with less than a 1% catalyst loading without using stoichiometric
reagents and further focus on developing a higher quality process using data-driven chemistry.

CONCLUSION AND OUTLOOK
Even with these findings, there remain significant opportunities for new innovation. I believe peptide
synthesis is truly a science of tomorrow, and I hope more young scientists join this amazing area.