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Page 4 of 6 Yamamoto. Chem Synth 2022;2:14 https://dx.doi.org/10.20517/cs.2022.12
Figure 4. New method using diketopiperazines.
Figure 5. Supersilyl as the key to high hydrophobicity.
Figure 6. Concept of non-peptide synthesis.
peptide synthesis. First, it enables a high reactivity of activation of carboxylic acid. Second, it enables the
reaction proceeds in three minutes at room temperature. Finally, it allows a substrate ratio of 1:1 to be used
for the process .
[10]
Environmentally benign purification
Since this basically is not a carboxylic acid activation method, racemization does not require consideration,
and because a hydrophilic supersilyl method is used, an ordinary simple short path column is sufficient
[Figure 8] .
[10]
