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Siddiqui et al. Chem Synth 2023;3:25 https://dx.doi.org/10.20517/cs.2023.02 Page 47 of 50

derivatization of natural products and existing drugs has emerged as an important research area. In the
future, further biotransformation studies will include the production of biologically important transformed
products in bulk quantities for their in vitro, ex vivo, and in vivo studies. After successful evaluation, these
compounds may serve as new therapeutic agents against various ailments. The mode of actions of potent
derivatives through NMR spectroscopy and molecular docking studies will also be performed. Moreover,
the biologically important metabolites need to be studied at enzymatic levels using modern molecular and
structural biology techniques in order to understand the Supplementary Figures involvedin the
biotransformation reactions.

DECLARATIONS
Acknowledgments
We would like to acknowledge present and past students and research officers of the biotransformation
laboratories whose names are cited in the references. Financial support from national and international
funding agencies is also appreciated here.

Authors’ contributions
Designed the topic and provided ideas: Choudhary M, Rahman A
Collected the data and drafted the review: Siddiqui M, Wahab A
Checked and finalized this review article: Choudhary M, Rahman A

Availability of data and materials
Not applicable.

Financial support and sponsorship
Not applicable.

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2023.

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