Page 50 - Read Online

Page 160 Lotz et al. Cancer Drug Resist 2020;3:149-60 I http://dx.doi.org/10.20517/cdr.2019.114

gate. Nat Commun 2018;9:3085.
67. Vanden Broeck A, Lotz C, Ortiz J, Lamour V. Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex. Nat
Commun 2019;10:4935.
68. Petrella S, Capton E, Raynal B, Giffard C, Thureau A, et al. Overall structures of mycobacterium tuberculosis DNA gyrase reveal the role
of a corynebacteriales GyrB-specific insert in ATPase activity. Structure 2019;27:579-89.e5.
69. Wendorff TJ, Schmidt BH, Heslop P, Austin CA, Berger JM. The structure of DNA-bound human topoisomerase II alpha: conformational
mechanisms for coordinating inter-subunit interactions with DNA cleavage. J Mol Biol 2012;424:109-24.
70. Agostinho M, Santos V, Ferreira F, Costa R, Cardoso J, et al. Conjugation of human topoisomerase 2 alpha with small ubiquitin-like
modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and chromosome domain specificity. Cancer Res 2008;68:2409-18.
71. Mao Y, Desai SD, Liu LF. SUMO-1 conjugation to human DNA topoisomerase II isozymes. J Biol Chem 2000;275:26066-73.
72. Blower TR, Bandak A, Lee ASY, Austin CA, Nitiss JL, et al. A complex suite of loci and elements in eukaryotic type II topoisomerases
determine selective sensitivity to distinct poisoning agents. Nucleic Acids Res 2019;47:8163-79.
73. Wessel I, Jensen LH, Renodon-Corniere A, Sorensen TK, Nitiss JL, et al. Human small cell lung cancer NYH cells resistant to the
bisdioxopiperazine ICRF-187 exhibit a functional dominant Tyr165Ser mutation in the walker A ATP binding site of topoisomerase II
alpha. FEBS Lett 2002;520:161-6.
74. Renodon-Corniere A, Jensen LH, Nitiss JL, Jensen PB, Sehested M. Analysis of bisdioxopiperazine dexrazoxane binding to human DNA
topoisomerase II alpha: decreased binding as a mechanism of drug resistance. Biochemistry 2003;42:9749-54.
75. Jensen LH, Wessel I, Moller M, Nitiss JL, Sehested M, et al. N-terminal and core-domain random mutations in human topoisomerase II
alpha conferring bisdioxopiperazine resistance. FEBS Lett 2000;480:201-7.
76. Miller ML, Ponten TS, Petersen TN, Blom N. NetPhosK - Prediction of kinase-specific phosphorylation from sequence and sequence-
derived features. Febs J 2005;272:111.