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Yamanaka et al. Vessel Plus 2020;4:39  I  http://dx.doi.org/10.20517/2574-1209.2020.46                                          Page 3 of 8

                           Table 1. Preoperative patient characteristics
                            Number                                        40
                            Age                                           77.0 ± 6.0 years (59-87)
                            Male                                          35 (87.5%)
                            Type of aneurysms
                              Fusiform distal aneurysm                    21 (52.5%)
                              Saccular type aneurysm                      14 (35%)
                              The extension of aneurysm                   4 (10%)
                              Penetrating aortic ulcer                    1 (2.5)
                            Hypertension                                  32 (80.0%)
                            DM (insulin)                                  9 (22.5%)
                            DL                                            16 (34.7%)
                            CVD                                           19 (47.5%)
                            Renal dysfunction (Cr ≥ 1.2)                  10 (25.0%)
                            COPD                                          13 (32.5%)
                            Precious aortic surgery                       6 (15.0%)
                           DM: diabetes mellitus; DL: dyslipidemia; CVD: cerebrovascular disease; Cr: creatinine; COPD:
                           chronic obstructive pulmonary disease


















               Figure 1. Procedure of total arch replacement with the frozen elephant trunk technique. The frozen elephant trunk was inserted through
               the transection site into the intended distal landing portion by guiding transesophageal echocardiography. We constructed the distal
               anastomosis with a separated 4-branched graft and antegrade systemic circulation was restarted through the side branch of the graft.
               The left common carotid artery and brachiocephalic artery were then anastomosed to their respective graft branches. After completion
               of the proximal anastomosis, the aortic graft was declamped and the 8 mm graft connected to the left subclavian artery was finally
               anastomosed with one branch of the graft


               bilateral upper extremities under cerebral perfusion in all cases. The aortic arch was dissected transversely
               between the left common carotid artery and the left subclavian artery. The FET was inserted through the
               transection site into the intended distal landing portion, which was positioned up to the T8 level to prevent
               spinal cord injury (SCI). We confirmed the distal end of the FET by transesophageal echocardiography
                    [6]
               (TEE) . We constructed the distal anastomosis with a separated 4-branched graft that was reinforced with
               Teflon felt strips and antegrade systemic circulation was restarted through the side branch of the aortic
               arch graft and the patient was rewarmed by extracorporeal circulation. The left common carotid artery and
               brachiocephalic artery were then anastomosed to their respective graft branches. After completion of the
               proximal anastomosis, the aortic graft was declamped and the 8mm graft connected to the left subclavian
               artery was finally anastomosed with one branch of the arch graft [Figures 1 and 2].

               Statistical analysis
               Continuous variables are expressed as the mean ± standard deviation. The Kaplan-Meier method was used
               to estimate mid-term outcome. Statview for Windows, version 5.0 (SAS Institute Inc., Cary, NC), was used
               for the statistical analyses. Data were presented as mean ± SD, as appropriate.
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