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Linger et al. Vessel Plus 2020;4:36 Vessel Plus
DOI: 10.20517/2574-1209.2020.51

Commentary Open Access

Frontiers in endovascular thrombectomy for
ischemic stroke

Matthew Linger , Bruce C. V. Campbell 1,2
1
1 Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne,
Parkville, Victoria 3050, Australia.
2 The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia.

Correspondence to: Prof. Bruce C. V. Campbell, Department of Neurology, Royal Melbourne Hospital, 300 Grattan Street,
Parkville, Victoria 3050, Australia. E-mail: bruce.campbell@mh.org.au
How to cite this article: Linger M, Campbell BCV. Frontiers in endovascular thrombectomy for ischemic stroke. Vessel Plus
2020;4:36. http://dx.doi.org/10.20517/2574-1209.2020.51
Received: 15 Sep 2020 First Decision: 9 Oct 2020 Revised: 25 Oct 2020 Accepted: 5 Nov 2020 Published: 18 Nov 2020

Academic Editor: Aaron S. Dumont Copy Editor: Cai-Hong Wang Production Editor: Jing Yu

Abstract
Received: First Decision: Revised: Accepted: Published: x
Stroke is a leading cause of morbidity and mortality worldwide. There have been significant advances in the
Science Editor: Copy Editor: Production Editor: Jing Yu hyperacute treatment of patients with ischemic stroke with the advent and application of reperfusion therapies,
including intravenous thrombolysis and endovascular thrombectomy. Endovascular thrombectomy involves the
removal of thrombus from an artery using a mechanical retriever or aspiration with angiographic visualization. This
review aims to outline the current evidence to support the use of endovascular thrombectomy and highlight areas
of ongoing research.

Keywords: Ischemic stroke, endovascular thrombectomy, thrombolysis, tenecteplase, tissue plasminogen activator,
alteplase, computed tomography perfusion, magnetic resonance imaging, randomized trial

EVIDENCE FOR ENDOVASCULAR THROMBECTOMY AND THE TIME WINDOW FOR

TREATMENT
The benefit of endovascular thrombectomy over standard medical care was proven in 2015, with 5 trials
[Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the
Netherlands (MR CLEAN); Extending the Time for Treatment in Emergency Neurological Deficits -
Intra-Arterial (EXTEND-IA); Endovascular Treatment for Small Core and Anterior Circulation Proximal

© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
and indicate if changes were made.

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