Page 273 - Read Online

Vasefi et al. Vessel Plus 2020;4:24 I http://dx.doi.org/10.20517/2574-1209.2020.16 Page 9 of 11

subtype of glutamate transporter through activation of phosphatidylinositol 3-kinase. J Biol Chem 2000;275:5228-37.
39. Krizman-Genda E, Gonzalez MI, Zelenaia O, Robinson MB. Evidence that Akt mediates platelet-derived growth factor-dependent
increases in activity and surface expression of the neuronal glutamate transporter, EAAC1. Neuropharmacology 2005;49:872-82.
40. Iihara K, Hashimoto N, Tsukahara T, Sakata M, Yanamoto H, et al. Platelet-derived growth factor-BB, but not -AA, prevents delayed
neuronal death after forebrain ischemia in rats. J Cereb Blood Flow Metab 1997;17:1097-106.
41. Kawabe T, Wen TC, Matsuda S, Ishihara K, Otsuda H, et al. Platelet-derived growth factor prevents ischemia-induced neuronal injuries in
vivo. Neurosci Res 1997;29:335-43.
42. Sakata M, Yanamoto H, Hashimoto N, Iihara K, Tsukahara T, et al. Induction of infarct tolerance by platelet-derived growth factor against
reversible focal ischemia. Brain Res 1998;784:250-5.
43. Egawa-Tsuzuki T, Ohno M, Tanaka N, Takeuchi Y, Uramoto H, et al. The PDGF B-chain is involved in the ontogenic susceptibility of the
developing rat brain to NMDA toxicity. Exp Neurol 2004;186:89-98.
44. Iihara K, Sasahara M, Hashimoto N, Uemura Y, Kikuchi H, et al. Ischemia induces the expression of the platelet-derived growth factor-B
chain in neurons and brain macrophages in vivo. J Cereb Blood Flow Metab 1994;14:818-24.
45. Suzuki J, Baba S, Ohno I, Endoh M, Nawata J, et al. Immunohistochemical analysis of platelet-derived growth factor-B expression in
myocardial tissues in hypertrophic cardiomyopathy. Cardiovasc Pathol 1999;8:223-31.
46. Lee JC, Kim YH, Lee TK, Kim IH, Cho JH, et al. Effects of ischemic preconditioning on PDGF-BB expression in the gerbil hippocampal
CA1 region following transient cerebral ischemia. Mol Med Rep 2017;16:1627-34.
47. Ohno M, Sasahara M, Narumiya S, Tanaka N, Yamano T, et al. Expression of platelet-derived growth factor B-chain and beta-receptor in
hypoxic/ischemic encephalopathy of neonatal rats. Neuroscience 1999;90:643-51.
48. Krupinski J, Issa R, Bujny T, Slevin M, Kumar P, et al. A putative role for platelet-derived growth factor in angiogenesis and
neuroprotection after ischemic stroke in humans. Stroke 1997;28:564-73.
49. Ishii Y, Oya T, Zheng L, Gao Z, Kawaguchi M, et al. Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are
vulnerable to injury. J Neurochem 2006;98:588-600.
50. Nikolakopoulou AM, Zhao Z, Montagne A, Zlokovic BV. Regional early and progressive loss of brain pericytes but not vascular smooth
muscle cells in adult mice with disrupted platelet-derived growth factor receptor-beta signaling. PLoS One 2017;12:e0176225.
51. Lewandowski SA, Fredriksson L, Lawrence DA, Eriksson U. Pharmacological targeting of the PDGF-CC signaling pathway for blood-
brain barrier restoration in neurological disorders. Pharmacol Ther 2016;167:108-19.
52. Shen J, Ishii Y, Xu G, Dang TC, Hamashima T, et al. PDGFR-beta as a positive regulator of tissue repair in a mouse model of focal
cerebral ischemia. J Cereb Blood Flow Metab 2012;32:353-67.
53. Shibahara T, Ago T, Nakamura K, Tachibana M, Yoshikawa Y, et al. Pericyte-mediated tissue repair through PDGFRbeta promotes peri-
infarct astrogliosis, oligodendrogenesis, and functional recovery after acute ischemic stroke. eNeuro 2020;7.
54. Shen J, Xu G, Zhu R, Yuan J, Ishii Y, et al. PDGFR-beta restores blood-brain barrier functions in a mouse model of focal cerebral
ischemia. J Cereb Blood Flow Metab 2019;39:1501-15.
55. Niu F, Yao H, Liao K, Buch S. HIV Tat 101-mediated loss of pericytes at the blood-brain barrier involves PDGF-BB. Ther Targets Neurol
Dis 2015;2:e471.
56. Niu F, Yao H, Zhang W, Sutliff RL, Buch S. Tat 101-mediated enhancement of brain pericyte migration involves platelet-derived
growth factor subunit B homodimer: implications for human immunodeficiency virus-associated neurocognitive disorders. J Neurosci
2014;34:11812-25.
57. Miners JS, Schulz I, Love S. Differing associations between Abeta accumulation, hypoperfusion, blood-brain barrier dysfunction
and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer’s disease. J Cereb Blood Flow Metab
2018;38:103-15.
58. Padel T, Ozen I, Boix J, Barbariga M, Gaceb A, et al. Platelet-derived growth factor-BB has neurorestorative effects and modulates the
pericyte response in a partial 6-hydroxydopamine lesion mouse model of Parkinson’s disease. Neurobiol Dis 2016;94:95-105.
59. Milesi S, Boussadia B, Plaud C, Catteau M, Rousset MC, et al. Redistribution of PDGFRbeta cells and NG2DsRed pericytes at the
cerebrovasculature after status epilepticus. Neurobiol Dis 2014;71:151-8.
60. Bethel-Brown C, Yao H, Hu G, Buch S. Platelet-derived growth factor (PDGF)-BB-mediated induction of monocyte chemoattractant
protein 1 in human astrocytes: implications for HIV-associated neuroinflammation. J Neuroinflammation 2012;9:262.
61. Jansson D, Scotter EL, Rustenhoven J, Coppieters N, Smyth LC, et al. Interferon-gamma blocks signalling through PDGFRbeta in human
brain pericytes. J Neuroinflammation 2016;13:249.
62. Hardy JA, Higgins GA. Alzheimer’s disease: the amyloid cascade hypothesis. Science 1992;256:184-5.
63. Barroeta-Espar I, Weinstock LD, Perez-Nievas BG, Meltzer AC, Siao Tick Chong M, et al. Distinct cytokine profiles in human brains
resilient to Alzheimer’s pathology. Neurobiol Dis 2019;121:327-37.
64. O’Brien RJ, Wong PC. Amyloid precursor protein processing and Alzheimer’s disease. Annu Rev Neurosci 2011;34:185-204.
65. Kim C, Jang CH, Bang JH, Jung MW, Joo I, et al. Amyloid precursor protein processing is separately regulated by protein kinase C and
tyrosine kinase in human astrocytes. Neurosci Lett 2002;324:185-8.
66. Gianni D, Zambrano N, Bimonte M, Minopoli G, Mercken L, et al. Platelet-derived growth factor induces the beta-gamma-secretase-
mediated cleavage of Alzheimer’s amyloid precursor protein through a Src-Rac-dependent pathway. J Biol Chem 2003;278:9290-7.
67. Zambrano N, Gianni D, Bruni P, Passaro F, Telese F, et al. Fe65 is not involved in the platelet-derived growth factor-induced processing
of Alzheimer’s amyloid precursor protein, which activates its caspase-directed cleavage. J Biol Chem 2004;279:16161-9.
68. Friedman R, Pellarin R, Caflisch A. Amyloid aggregation on lipid bilayers and its impact on membrane permeability. J Mol Biol