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Antonazzo et al. Vessel Plus 2020;4:3  I  http://dx.doi.org/10.20517/2574-1209.2019.33                                                Page 5 of 8  Table 3. Selected studies on TAVI in the elderly



                                                                                                     Ref.
                                                     Oh (2019)
                                                                Kim (2019)
                                                                                 Eide (2015)
                                                   Okoh (2019)
                                                                                    Drudi (2018)
                                                                             Gertz (2014)
                                                                                        Ciuca (2017)
                                                Olsen (2017)
                                              Orvin (2014)
                                 Urena (2015)
                                     Russo (2014)
                                                                         Green (2012)
                                                                  Kamga (2013)
                                                                    Kagase (2018)
                                                       Nagura (2019)
                                                                                               Bordoni (2015)
                                                                                                 Bogdan (2016)
                                                         Murata (2019)
                                                                               Elgendy (2019)
                                                           Mentias (2019)
                                                                                                   Amofah (2016)
                                            Piccirillo (2018)
                                                                                            Boreskie (2019)
                                                                      Instenes (2018)
                                                              Lindman (2016)
                                                                           Goldfarb (2018)
                                                                                      de Thézy (2017)
                                          Rabinovitz (2016)
                             Zemedkun (2015)
                                                                                          Cavalcante (2017)
                                   Schoenenberger (2013)
                               Zalenska-Kociecka (2019)
                                        Raposeiras-Roubín (2016)
                                                           31668118
                                                              27113148
                                                                31587128
                                                                                          29212513
                                                     31514956
                                                                                            31543187
                                                                    29301641
                                                                                               26378413
                                                                                      29187325
                                                                      28396186
                                                                         22331630
                                                                                                 27159658
                                                                               30569661
                                     23757283
                               30718946
                                                                                                   26635329
                                                                             23704061
                                        27573609
                                                                  24579438
                                                                                 25644851
                                                         31462606
                                 25466975
                                                                           29976568
                                            30237702
                                                27036955
                                              24481462
                                                                                    29344620
                                                   30618060
                             25982494
                                          26936468
                                                                                        28585899
                                   23008508
                                                       30599060
                                                                                                     PubMed ID
                                                                                            Review
                                                              Review
                               Review
                                                                                                     Design
                                                                Diagnostic study
                                                                                      Diagnostic study
                                                                             Diagnostic study
                                                                      Qualitative study
                                                                                        Observational study
                                                                                          Observational study
                                                                           Observational study
                                                                    Observational study
                                                                  Observational study
                                                                                 Observational study
                                                                         Observational study
                                                                                    Observational study
                                                                               Observational study
                                                                                               Observational study
                                                   Observational study
                                                     Observational study
                                        Observational study
                                                Observational study
                                                                                                 Observational study
                                            Observational study
                                          Observational study
                                              Observational study
                                                                                                   Observational study
                                                           Observational study
                                                         Observational study
                                 Observational study
                             Observational study
                                     Observational study
                                   Observational study
                                                       Observational study
                                                                      10
                                                                             51
                                     78
                                              36
                             54
                                        54
                                                                                      49
                                                         58
                                                65
                                                                  30
                                                                                        62
                                            40
                                                                                          113
                                                                                            NA
                                                              NA
                                                                                                   143
                               NA
                                                                                 143
                                                     261
                                                                         102
                                                                                                 150
                                   106
                                          302
                                                                                               224
                                                                    927
                                 435
                                                                           1158
                                                   1160
                                                                                    1035
                                                       1004
                                                                2583
                                                                               6680
                                                           13,544
                                                                                                     Patients
                                                                                                 Albumin predicts long-term outcomes after TAVI
                                                                CT can reliably recognize bicuspid AS in the elderly
                                        NT-proBNP predicts long-term outcomes after TAVI
                                                              Multimorbidity is common in elderly patients with AS
                                                                    Grip strength predicts long-term outcomes after TAVI
                                                   Discharge disposition impacts on post-TAVI outcomes
                                   Post-TAVI functional decline is predicted by frailty scores
                                                         Ventilatory efficacy predicts long-term outcomes after TAVI
                                                                         Gait speed is associated with ADL in elderly patients with AS
                                                                                            Prehabilitation may be beneficial in patients with AS awaiting TAVI
                                                                                                     Highlights
                                              TAVI impacts favorably on functional performance and cognitive function
                                          Admission Norton scale score independently predicts post-TAVI mortality
                                                                                      The G8 tool is a useful screening scale for frailty in elderly patients with AS
                                                                  The SHERPA frailty score in an independent predictor of post-TAVI outcome
                                                                             Oxygen consumption is best estimated with a modified mathematical formula
                                                     Long-term outcomes are similar with TAVI and SAVR in low-risk elderly patients
                                                                                 Postoperative delirium is less common with TAVI than with SAVR in octogenarians
                                            The 12-lead-ECG-derived electrical risk score predicts long-term outcomes after TAVI
                                                TAVI improves self-reported global health and generic physical health and quality of life
                                 Arrhythmias are common in elderly patients with AS and predict post-TAVI adverse events
                                                                      Postoperative delirium is common after TAVI and SAVR, and its memories persist long-term
                                                       Post-procedural valvuloarterial impedance is not associated with increased mortality after TAVI
                                     Early cardiac rehabilitation enhances independence, mobility, and functional capacity after TAVI
                       surgical aortic valve replacement; SHERPA: Score Hospitalier d’Evaluation du Risque de Perte d’Autonomie; TAVI: transcatheter aortic valve implantation; NA: not applicable
                                                                               TAVI is associated with similar mortality but less morbidity than SAVR in nonagenarians with AS
                             A low-dose contrast protocol for CT is associated with reduced contrast volume in patients with AS
                                                                                               Repeat BAV is a reasonable management strategy in elderly patients who are not candidate for TAVI
                                                                           Preprocedural nutritional status is associated with mortality in older adults undergoing TAVI or SAVR
                                                                                        Cognitive impairment is common in elderly patients with AS but is not significantly impacted by TAVI
                                                                                          Cardiac amyloidosis is common in elderly patients with AS and predicts adverse outcomes after TAVI
                                                                                                   Sleep is disturbed in patients with AS, and may improve after SAVR and TAVI, albeit less with the latter
                               AKI is common in patients undergoing TAVI and can be predicted by means of multidimensional risk appraisal
                                                           Outcomes of TAVI in nonagenarians have improved by considering the impact of early complications on long-term events
                                                                                    Depression is common in patients awaiting TAVI, and it predicts adverse outcomes, especially if persisting after the procedure
                         ADL: activities of daily living; AKI: acute kidney injury; AS: aortic stenosis; BAV: balloon aortic valvuloplasty; CT: computed tomography; NT-proBNP: N-terminal pro-brain natriuretic peptide; SAVR:
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