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Pragliola et al. Vessel Plus 2019;3:22 Vessel Plus
DOI: 10.20517/2574-1209.2019.003

Review Open Access

Del Nido cardioplegia: from an infant conceive to an
adult life - a brief review of the current evidence in

adult patients

Claudio Pragliola , Essam Hassan , Abdulaziz Al Hossan , Khaled Al Otaibi , Juan J. T. Alfonso , Afnan
1
1
1,3
1
1,2
Al Khalaf , Khalid D. Al Garni 1,4
1
1 Prince Sultan Military Cardiac Centre, Riyadh 11564, Saudi Arabia.
2 Dipartimento Scienze Cardiovascolari, Università Cattolica, Roma 00198, Italy.
3 Department of Cardiac Surgery, Tanta University, Tanta 31527, Egypt.
4 Department of Cardiac Sciences, King Saud University, Riyadh 12372, Saudi Arabia.
Correspondence to: Dr. Claudio Pragliola, Consultant Cardiac Surgeon, Prince Sultan Military Cardiac Centre, Building 6
Makka Makkarrama Road 12323 Al Sulimanyah, Riyadh 11564, Saudi Arabia. E-mail: mailto:claudio.pragliola@libero.it;
mailto:cpragliola@pscc.med.sa
How to cite this article: Pragliola C, Hassan E, Al Hossan A, Al Otaibi K, Alonso JJT, Al Khalaf A, Al Garni KD. Del Nido cardioplegia:
from an infant conceive to an adult life - a brief review of the current evidence in adult patients. Vessel Plus 2019;3:22.
http://dx.doi.org/10.20517/2574-1209.2019.003

Received: 24 Mar 2019 First Decision: 18 Apr 2019 Revised: 26 Apr 2019 Accepted: 24 May 2019 Published: 18 Jun 2019
Received: First Decision: Revised: Accepted: Published: x
Science Editor: Mario F. L. Gaudino Copy Editor: Cai-Hong Wang Production Editor: Jing Yu
Science Editor: Copy Editor: Production Editor: Jing Yu

Abstract

The increasing number of minimally invasive procedures prompted the quest for a simple and effective single
shot cardioplegia to allow the surgeons to focus on their workflow. The originally pediatric Del Nido solution was
successfully tested in several centers and gradually extended to regular coronary and valvular cases. In the present
review we report the current evidence on the use of the Del Nido solution in adult patients.

Keywords: Del Nido cardioplegia, adult cardioplegia, myocardial protection, blood cardioplegia, single shot
cardioplegia

INTRODUCTION
Adult cardiac surgery has changed in the last decade. In the 2018 the STS database reports that about 75%
[1]
of the patients submitted to myocardial revascularization had 3 or more grafts with an increasing number
of non-elective procedures, diabetic and heart failure patients. At the same time 23% of the all the isolated

© The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0
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sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
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