Page 310 - Read Online

Martínez et al. Vessel Plus 2018;2:32 Vessel Plus
DOI: 10.20517/2574-1209.2018.68

Correction Open Access

Correction: Energetic metabolism in cardiomyocytes:
molecular basis of heart ischemia and arrhythmogenesis

María Sofía Martínez , Andrés García , Eliana Luzardo , Mervin Chávez-Castillo , Luis Carlos Olivar , Juan
1
1
1
1
1
Salazar , Manuel Velasco , Joselyn Joanna Rojas Quintero , Valmore Bermúdez 1,4
1,3
2
1
1 Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela.
2 Department of Pharmacology, “JM Vargas” Medical School, Central University of Venezuela, Caracas 1051, Venezuela.
3 Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
4 Advanced Frontier Studies Research Group (ALEF), Simón Bolívar University, Cúcuta 54003, Colombia.
Correspondence to: Dr. María Sofía Martínez, Endocrine and Metabolic Diseases Research Center, School of Medicine, University
of Zulia, Maracaibo 4001, Venezuela. E-mail: mmartinez@fmed.luz.edu.ve
How to cite this article: Martínez MS, García A, Luzardo E, Chávez-Castillo M, Olivar LC, Salazar J, Velasco M, Quintero JJR,
Bermúdez V. Vessel Plus 2018;2:32. http://dx.doi.org/10.20517/2574-1209.2018.68
Received: 26 Sep 2018 First Decision: 26 Sep 2018 Revised: 11 Oct 2018 Accepted: 11 Oct 2018 Published: 23 Oct 2018
Science Editor: Mario F. L. Gaudino Copy Editor: Cui Yu Production Editor: Huan-Liang Wu

The original article was published on 28 Dec 2017.

After the publication of the article named “Energetic metabolism in cardiomyocytes: molecular basis of heart
[2]
[1]
ischemia and arrhythmogenesis” , we found that the article by Stanley et al. was unwisely omitted from
the fourth paragraph of the section titled “Fuel for myocardial contraction: the role of macromolecules”.
This reference should be cited in the first, third and fourth sentences of this section, namely “The
metabolic machinery of the heart utilizes oxygen up to 80%-90% of the maximum capacity of the electron
transport chain; however, at a resting state, the heart operates at only 15%-25% of its maximum oxidative
capacity”, “Cardiomyocytes show an elevated rate of ATP hydrolysis, which is strongly linked to oxidative
phosphorylation. Because under non-ischemic conditions, over 95% of these cells’ ATP is produced in this
process, it is indispensable in order to assure the full replenishment of the cardiomyocytes’ ATP content
every 10 s, and thus maintain constant concentrations of this molecule, even under conditions of increased
frequency or force of contractions” and “Of the total energy produced by ATP hydrolysis, approximately
2+
60%-70% serves as fuel for contraction, while the remaining 30%-40% is used by the Ca ATPase pumps in
the smooth sarcoplasmic reticulum and other ion pumps”.

REFERENCES
1. Martínez MS, García A, Luzardo E, Chávez-Castillo M, Olivar LC, Salazar J, Velasco M, Quintero JJR, Bermúdez V. Energetic
metabolism in cardiomyocytes: molecular basis of heart ischemia and arrhythmogenesis. Vessel Plus 2017;1:230-41.
2. Stanley WC, Recchia FA, Lopaschuk GD. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 2005;85:1093-
129.
© The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
and indicate if changes were made.

www.vpjournal.net