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Singh et al. Myocardial protection in cardiac transplantation

by RIC at cross-clamp times of 57-75 min (ratio of RIC/ Table design: S. Das De
control = 0.757; P = 0.0348) and of ≥ 76 min (ratio of Reviewing, editing, supervision: C. Spadaccio, C.
RIC/control = 0.735; P = 0.0277) [146] . RIC theoretically Berry, N. Al-Attar
confers protection against ischaemia but not trauma
during surgery (cannulation/handling); thus making Financial support and sponsorship
it plausible that in longer cross-clamp times, the None.
protection conferred by RIC becomes more overt due
to the effect of ischaemic/reperfusion injury. Another Conflicts of interest
recent study what studied the effect of preconditioning There are no conflicts of interest.
with cyclosporine-A (which prevents MPTP opening
at the onset of reperfusion, thereby also reducing Patient consent
the incidence of ischaemic-reperfusion injury [147] in Not applicable.
patients undergoing elective CABG revealed similar
findings, with the cardioprotective benefits noted at Ethics approval
longer cross-clamp times (85-120 min) but not in the Not applicable.
shorter (50-85 min) group [148] .
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