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POAF may not associate with differences in gender-based survival .
These limitations notwithstanding, this ROOBY-FS 10-year investigation shows that patients who
experience postoperative atrial fibrillation after CABG are more likely to have 10-year atrial fibrillation and
reduced survival at the time of long-term follow-up. At the time of discharge, patients with POAF may
benefit from counsel to alert them that it is possible their AF may persist or recur and that assessment and
counsel on the risk-benefit ratio of long-term anticoagulation may ultimately be necessary. Patients with
POAF who have higher rates of co-morbidities may benefit from prospective studies to determine whether
more frequent monitoring and sustained management of these associated health issues could reduce their
long-term risk of atrial fibrillation and death.
DECLARATIONS
Acknowledgments
Special thanks to Annette Wiseman, Darlene Kemp and Shirley Lu at the Perry Point Cooperative Studies
Program Coordinating Center for their extraordinary administrative, clinical and analytic support as well as
to the Research and Development Offices of the Northport VA Medical Center.
Author’s contributions
Provide substantive intellectual manuscript contributions: Quin JA, Almassi GH, Collins JF, Carr BM,
Grover FL, Shroyer AL
Conceptualize the design, participate in data acquisition, and help to guide the analytical reports produced,
as well as interprete findings: Shroyer AL, Quin JA, Almassi GH
Interprete analytical reports as part of collaborative team discussions: Carr BM, Grover FL
Produce all statistical analytical reports as well as their official interpretation: Collins JF
Drafted the first manuscript and coordinated all manuscript revisions including the final manuscript’s
review/approval with all other co-authors (i.e., Shroyer AL, Carr BM, Grover, FL, and Almassi GH): Quin J
Provide review and approval of this final study manuscript: Quin JA, Almassi GH, Collins JF, Carr BM,
Grover FL, Shroyer AL
Availability of data and materials
The ROOBY-FS protocol, published by the New England Journal of Medicine, can be accessed at:
https://www.nejm.org/doi/suppl/10.1056/NEJMoa1614341/suppl_file/nejmoa1614341_protocol.pdf. Source
documents are available upon written request from Ms. Annette Wiseman at the Department of Veterans
Affairs Cooperative Studies Program Coordinating Center in Perry Point, Maryland
(Annette.Wiseman@va.gov) and ROOBY-FS data will be made publicly available per Department of
Veterans Affairs policies five years after publication of the final 10-year main manuscript’s results.
Financial support and sponsorship
Funding for the current study was provided by the Department of Veterans Affairs Cooperative Studies
Program through the Cooperative Studies Program Coordinating Center at Perry Point, Maryland (Director
Dr. Kousick Biswas and Project Administrator Ms. Annette Wiseman).
Conflicts of interest
All authors declared that there are no conflicts of interest.
Ethical approval and consent to participate
This study was conducted in accordance with the Helsinki Declaration with ethical approvals for the
ROOBY-FS investigation obtained through the Perry Point Cooperative Studies Program Coordinating