Page 70 - Read Online
P. 70
Page 12 of 14 Abdel-Halim et al. Vessel Plus 2022;6:8 https://dx.doi.org/10.20517/2574-1209.2021.40
considered and tailored according to the needs of each patient in a way that improves his/her quality of
[55]
life .
CONCLUSION
Cutaneous manifestations are common in AAV. They may be the presenting manifestation of the disease,
occur during its course, or mark a disease relapse. They may be specific or non-specific according to the
presence or absence of vasculitis with or without granulomas in skin biopsies. They are usually associated
with severe systemic manifestations and multiple organ involvement. Since such lesions can occur in other
types of systemic vasculitis and in other disorders, linking them with AAV requires meticulous clinical,
laboratory, and serological correlation.
DECLARATIONS
Authors’ contributions
Made substantial contributions to conception and design of the manuscript, writing, editing, provision of
clinical photos and histopathological photomicrographs: Abdel-Halim M
Contributed to writing the manuscript: Mahmoud A
Planning, supervising, revision of the manuscript and editing: Ragab G
Availability of data and materials
Not applicable.
Financial support and sponsorship
None.
Conflicts of interest
All authors declared that there are no conflicts of interest.
Ethical approval and consent to participate
Not applicable.
Consent for publication
Not applicable.
Copyright
© The Author(s) 2022.
REFERENCES
1. Cornec D, Cornec-Le Gall E, Fervenza FC, Specks U. ANCA-associated vasculitis - clinical utility of using ANCA specificity to
classify patients. Nat Rev Rheumatol 2016;12:570-9. DOI PubMed
2. Micheletti RG, Chiesa Fuxench Z, Craven A, Watts RA, Luqmani RA, Merkel PA; DCVAS Investigators. Cutaneous manifestations
of antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheumatol 2020;72:1741-7. DOI PubMed
3. Francès C, Du LT, Piette JC, et al. Wegener’s granulomatosis. Dermatological manifestations in 75 cases with clinicopathologic
correlation. Arch Dermatol 1994;130:861-7. PubMed
4. Kluger N, Pagnoux C, Guillevin L, Francès C; French Vasculitis Study Group. Comparison of cutaneous manifestations in systemic
polyarteritis nodosa and microscopic polyangiitis. Br J Dermatol 2008;159:615-20. DOI PubMed
5. Comarmond C, Pagnoux C, Khellaf M, et al; French Vasculitis Study Group. Eosinophilic granulomatosis with polyangiitis (Churg-
Strauss): clinical characteristics and long-term followup of the 383 patients enrolled in the French Vasculitis Study Group cohort.
Arthritis Rheum 2013;65:270-81. DOI PubMed
6. Ragab G, Hegazy MT, Ali M, Abdel-Halim MRE, Puéchal X. Three patterns of cutaneous involvement in granulomatosis with
polyangiitis. J Adv Res 2020;24:311-5. DOI PubMed PMC
7. Daoud MS, Gibson LE, Deremee RA, Specks U, el-Azhary RA, Daniel Su W. Cutaneous Wegener's granulomatosis: clinical,
histopathologic, and immunopathologic features of thirty patients. J Am Acad Dermatol 1994;31:605-12. DOI PubMed