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Gerasimovskaya et al. Vessel Plus 2019;3:11 I http://dx.doi.org/10.20517/2574-1209.2019.11 Page 3 of 3

The circadian clock is the cellular signaling mechanism, which controls a daily cycle of biological
activities based on 24 h rhythmic oscillations. It well established that circadian clock components control
cardiovascular remodeling and disruption of circadian clock genes results in alterations in rhythmic
blood pressure, endothelial dysfunction thus contributing to cardiovascular diseases like atherosclerosis.
[6]
The original research article of Anea et al. analyses expression of circadian clock proteins through
cardiovascular tissues using immuno-histochemical approach. The studies revealed tissue-specific
differences in expression and localization of circadian clock proteins in vasculature suggesting the existence
of fine-tuned tissue-specific mechanisms of circadian clock regulation.

DECLARATIONS
Acknowledgments
The Guest Editors of this Special Issue sincerely appreciates and thank all contributors for their great efforts
to presenting their overviews on the interesting and important topics and research work to this special issue.
Our appreciation also goes to all the reviewers who have provided invaluable comments and suggestions for
the further improvement of the quality of the manuscripts. We also appreciated highly professional support
from the editorial stuff of the journal.

Authors’ contributions
The authors are equally contributed to the article.

Availability of data and materials
Not applicable.

Financial support and sponsorship
None.

Conflicts of interest
Both authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2019.

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