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Page 8 of 15                                        Lane et al. Plast Aesthet Res 2020;7:51  I  http://dx.doi.org/10.20517/2347-9264.2020.106

               Table 1. Flap selection for phalloplasty
                Staging                       Advantages                          Disadvantages
                Radial forearm free flap Phallus and pars pendula reconstruction with one flap  Aesthetically unpleasing donor site
                                 Long pedicle                         Skin graft needed for donor site
                                 Reliable anatomy                     Donor site sensory disturbance and neuroma possible
                                 High density of nerve innervation    Phallus length limited by forearm length
                                 Thin flap in obese and overweight patients
                Anterolateral thigh flap  Phallus and pars pendula reconstruction with one flap  Thick flap in overweight and obese patients
                                 Long pedicle                         Skin graft needed for donor site
                                 Flap can be pedicled                 Variable perforator anatomy
                                 Easily concealable donor site
                Latissimus flap  Reliable anatomy                     No cutaneous sensation
                                 Long pedicle                         Must perform pars pendula reconstruction in second
                                 Muscle can be reinnervated and cause “pseudo-  stage
                                 erection”
                                 Concealable donor site
                Superior circumflex iliac  Can be used as a pedicled flap  Two flaps needed for phallus and pars pendula
                perforator flap  Minimal donor site morbidity         reconstruction
                                                                      Thick abdominal flaps in overweight patients
                                                                      Limited ability to restore sensory innervation in the
                                                                      phallic skin
                Free fibula flap  Has rigidity for sexual intercourse  There is constant phallus rigidity
                                                                      Short pedicle
                                                                      Morbid donor site
                                                                      Phallus length limited by length of fibula harvest to
                                                                      preserve ankle mortise and fibular head
               There are a variety of donor sites for phalloplasty, with the most common being the radial forearm free flap. There is variation based on
               advantages and disadvantages according to the individual patient and institution

               Pars fixa urethra (also referred to as the perineal urethra)
               Among centers that perform masculinizing GCS, there is a wide diversity of specific technical details for
               pars fixa construction. The specific techniques for pars fixa reconstruction have been reported elsewhere
               (see references below) and are beyond our purpose and scope here. That said, the nearly universal strategy
               is to use adjacent tissues, sometimes augmented with skin or buccal mucosal grafts, to construct a hairless,
               epithelial-lined tube from the location of the female urethral orifice to the base of the neophallus. The
               variations in specific techniques include (1) the degree of clitoral chordee release and resection of clitoral
               skin performed when repositioning the clitoral body [38,59-61] ; (2) the timing of vaginectomy and the use (or
               not) of an anterior vaginal myomucosal turnover flap to augment the proximal pars fixa [20,21,62] ; (3) the use
               (or not) of skin or buccal mucosal grafts to form the dorsal “floor” of the pars fixa [61-65] ; (4) the specifics of
               labia minora pedicled flaps to construct the ventral “roof” of the pars fixa [60-65] ; (5) the timing of pars fixa
               construction (discussed below); and (6) the use (or not) of a pedicled gracilis muscle or other vascularized
               flap to augment healing of the multiple anastomotic suture lines necessary [66,67] . These variations have
               been employed in virtually every combination at various centers. Most importantly, the reported
               urethral complication rates vary most between centers, and not between specific surgical techniques
               or from differences in staging. That is, no single specific technique or staging strategy has convincingly
               demonstrated reduced urethral complications.

               Pars pendulans urethra (also referred to as the penile urethra)
               Variations in reconstruction of the penile urethra are largely a function of the specific flap used to construct
               the neophallus. As already mentioned, an advantage of the RFFF is that it is thin and pliable with robust
               vascularity, allowing construction of the penile urethra at the time of free-flap phalloplasty using the tube-
                                         [28]
               in-a-tube technique [Figure 3] . It has been hypothesized that the very large skin island necessary to do a
               one-stage penile urethral construction at the time of phalloplasty requires pushing the limits of the vascular
               territory of the RFFF and that this may account for the high rates of urethral complications; specific
                                                                                 [68]
               technical modifications may improve vascularity in the final RFFF territory . Although using the ALT
               in a similar one-stage fashion has been described, the bulkiness of the flap precludes this approach in the
                                [69]
               majority of patients .
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