Page 15 - Read Online

Page 4 of 8 Dobke et al. Plast Aesthet Res 2020;7:1 I http://dx.doi.org/10.20517/2347-9264.2019.65

Figure 1. Nano technology for skin care: From “Capture Totale” antiaging cream - skin cosmeceutical utilizing nano-liposomal
technology for improved transepidermal and percutaneous delivery introduced by Dior® and representing technology with moisture-
loaded liposomes which reduce skin water deprivation - to “Atelokolagen” by Colway which contains sericin - capable of carrying both
hydrophilic and hydrophobic agents with intracellular uptake

Figure 2. Crows feet skin wrinkles before and after daily application of nano-collagen for 3 weeks (Marine Collagen Biologicals, Inc., San
Diego, CA). Results were less spectacular in other cases, however, perhaps due to different individual nuclear gene expression profiles
and skin biology [16]

Topical and cutaneous delivery of cosmeceuticals evolved from formulations utilizing nano systems to
enhance percutaneous delivery of tissue-rejuvenating agents (e.g., the first nano cream Capture Totale
developed by Dior®, France) to agents with nanocarriers ensuring specific targeted extra- or intracellular
cosmeceutical delivery (e.g., sericin containing Atelokolagen developed by Colway, Poland) [Figure 1] [4,13] .
Certainly, variability in tissue rejuvenating techniques and agents depends not only on the modality of
delivery, including surgery, but also on the pheno- and genotypic characteristics of the subject. Currently,
personalized cosmetic selection to effectively target specific features is likely mostly through empiric processes
which lead to the establishment of an individualized beauty and rejuvenation “regimen” [14,15] [Figure 2].

It is probably only a matter of time until personalized skin care and facial rejuvenation techniques will
include interventions on a genotypic level (e.g., by shutting down unfavorable genes) or by triggering
[16]
regenerative processes . These beliefs and modalities were consistently demonstrated and highly ranked
within the plastic surgery community [5,16] . Transcription factors activate gene supporting processes which
lead to cell repair and such factors as forkhead-box protein O3a have a high capacity to preserve skin DNA in
younger individuals. As with aging agents, such as sericin, which may be useful to counteract the reduction
of cells’ capacity for self-repair and dermal regeneration, enhancing the targeted delivery of cosmeceuticals
to tissues and even cellular organelles may ultimately reduce and/or reverse skin “decay” [1,4,5] [Figure 3].

Surveyed physicians recognized that there is a growing level of evidence that mesenchymal stem cells from
adipose tissue and perivascular cellular components exert a strong potentiating effect on angiogenesis,