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Dobke et al. Plast Aesthet Res 2020;7:1 Plastic and
DOI: 10.20517/2347-9264.2019.65 Aesthetic Research

Review Open Access

Targeting facial aging with nano and regenerative

technologies and procedures

Marek Dobke, Adam Hauch

Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California San Diego, San Diego, CA 92103, USA.

Correspondence to: Prof. Marek Dobke, Division of Plastic and Reconstructive Surgery, Department of Surgery, UC San Diego, 200
West Arbor Drive, San Diego, CA 92103-8890, USA. E-mail: mdobke@health.ucsd.edu

How to cite this article: Dobke M, Hauch A. Targeting facial aging with nano and regenerative technologies and procedures. Plast Aesthet
Res 2020;7:1. http://dx.doi.org/10.20517/2347-9264.2019.65

Received: 30 Nov 2019 First Decision: 2 Jan 2020 Revised: 2 Jan 2020 Accepted: 7 Jan 2020 Published: 16 Jan 2020

Science Editors: John Yousif, Kai O. Kaye Copy Editor: Jing-Wen Zhang Production Editor: Tian Zhang

Abstract
This study reviews information about the most novel ideas and modalities being incorporated into facial and neck
cosmetic care. We seek to identify trends and developments within these areas as well as perceptions of plastic
surgeons regarding their probable significance, and discussion on how these modalities may impact future practice
patterns. It is hypothesized that nano and regenerative technologies are considered the most “hopeful”. Emerging
invasive and non-invasive modalities utilizing nano and regenerative concepts were reviewed. We intentionally
sought to investigate approaches to beautification, including maintenance and reversal of signs of aging, utilizing
methods lacking an established level of evidence. This included promising modalities which are currently at the
investigational stage. Twelve board-certified plastic surgeons were surveyed regarding the clinical importance
of twelve concepts and their expected impact on facial and neck rejuvenation. Scientific and technological
creativity in aesthetics is rapidly changing, and the efficacy of innovations and safety margins are improving.
Nano and regenerative medicine-based technologies and procedures were ranked most promising for the future
of cosmetics. Their potential applications and research were reviewed in the context of surgical and non-surgical
modalities in clinical practice. There has been an advent of new approaches to facial and neck aesthetic surgery
and tissue care, which is well-beyond just skin care. With this new level of knowledge regarding variability in
care responses and indications for procedures on an almost “molecular level”, personalized and precise aesthetic
surgery and medicine are quickly becoming a reality.

Keywords: Face, neck rejuvenation, nano, regenerative technologies

© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
and indicate if changes were made.

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