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12 h for 3 days and finally 50 mg hydrocortisone every shock and unresponsive to fluids and vasopressor
[9]
24 h for 3 days) or placebo groups. The results indicated administration.
no significant difference in mortality between treatment Review of the literature indicates the need to conduct
and the placebo group. But shock reversal was achieved carefully planned clinical trials to resolve controversies
more quickly in treatment group compared to the placebo and to provide a more reliable result. [13]
group, regardless of the adrenal function (P = 0.001).
However, the proportion of patients, in whom shock Financial support and sponsorship
reversal was achieved, was similar between the 2 groups. Nil.
There was also evidence of increased risk of superinfection
in treatment group (combined odds ratio: 1.37; 95% Conflicts of interest
confidence interval: 1.05‑1.79). The strength of the study There are no conflicts of interest.
was its large sample size, randomization and power of
study was 80%. The limitation of this study is that the REFERENCES
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