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dressings,  has been  shown to have a positive  effect   Of 140 patients, 56 participants (22 in the LAD group and 34
          on  wound healing.   The  aim  of  the  present  study  is  to   in the conventional dressing group) were lost to follow‑up
                          [8]
          determine the effect of LAD on wound surface pH.    or withdrawn from the study. Of 42  patients in the LAD
                                                              group, 22  (52%) were women, and 20  (48%) were men. In
          METHODS                                             the conventional dressing group, of 42 patients, 18 (42.8%)
                                                              were women, and 24 (57.1%) were men [Figure 1].
          Ethical issues                                      In the LAD group, the mean age was 38.3 ± 10.56 years
          This randomized control trial was carried out in the Burns   (range: 12‑60  years),  and the  mean  wound size  at  the
          and Plastic  Surgery  Department  of Kasturba Medical   time  of admission was 28 cm  (range: 19‑40  cm ). In
                                                                                                           2
                                                                                          2
          College and Hospital, Manipal, Keanataka, India. The study   the  conventional dressing  group, the  mean  age  was
          protocol was reviewed  and approved by  the  Institutional   35.3 ± 14.0  years  (range: 17‑65  years),  and the  mean
          Ethics  Committee.  The study was conducted as per   wound size at the time  of admission was 26 cm
                                                                                                              2
          approved protocol after obtaining informed consent from   (range: 18‑39 cm ) [Table 1].
                                                                            2
          all patients.
                                                              Patients in the LAD group were treated with intermittent
          Study design and randomization                      negative pressure.  In the conventional closed dressing
                                                                              [8]
          Two hundred  and fifteen patients with  chronic wounds   group, patients were dressed daily with 5% povidone‑iodine
          of more than 4 weeks duration were screened in the   solution soaked gauze. The wounds of both groups were
          study. Patients were evaluated for inclusion criteria   washed daily.
          (nonhealing chronic wounds) and exclusion criteria
          (collagen disorders, diabetes, leprosy, cirrhosis, HIV and   Assessment of wound surface pH
          pregnancy), and 140 patients were enrolled in the study.   The surface pH was measured by a pH paper strip
          Simple randomization was performed (www.random.org;   (Merck, Mumbai, India) placed on the surface of the
          random number table was prepared) with assigned numbers   wound with care taken to ensure accuracy. [9]
          and treatment sealed in opaque envelopes.           Statistical analysis
          One hundred and forty patients with a mean age of   Data obtained from both groups were analyzed using the
          36.86  ±  12.4  years  (range:  12‑65  years)  were  randomized   Student’s  t‑test  SPSS,  15th version,  SPSS  Inc.,  Chicago.
          and assigned to the LAD group (n = 64) or the conventional   The data  (mean  ±  SD) were compared between  the two
          dressing group (n = 76) by simple randomization [Figure 1].   groups. A P < 0.05 was taken as statistically significant.












































          Figure 1: Consort flowchart

           258                                                           Plast Aesthet Res || Vol 2 || Issue 5 || Sep 15, 2015
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