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Page 2 of 15                 Ali et al. Plast Aesthet Res 2021;8:35  https://dx.doi.org/10.20517/2347-9264.2021.29

               Keywords: Free tissue transfer, head and neck reconstruction, perforator mapping, technology, microvascular
               couplers, three-dimensional exoscope, fluorescent angiography, postoperative monitoring



               INTRODUCTION
               Free tissue transfer (FTT) has become a cornerstone of modern head and neck surgery, as it offers a unique
               means of reconstructing complicated skin, soft tissue, and osseous defects. As overall success rates continue
               to improve, head and neck surgeons are increasingly turning to FTT as a means of restoring form and
                                                                              [1]
               function for patients with operative and traumatic head and neck defects . Since its inception, significant
               advances in the operation and technological practice of the field have greatly reduced surgical duration and
                                                                                        [2]
               length of inpatient stay, two key metrics in sustaining a high-volume FTT practice . In particular, the
               coordination of a two-team approach, the advent of the microvascular coupling device, and the exploration
               of easily accessible, reliable donor site options have significantly reduced operative time. As technological
               advancements become more widely accessible, every aspect of the care provided to head and neck cancer
               patients has evolved, from the preoperative planning to postoperative monitoring. This chapter will explore
               recent technological advancements and their impacts on the modern FTT practice. An overview of the
               various technologies can be found in Table 1.


               PREOPERATIVE
               Preoperative planning, including flap donor site selection, is imperative to decrease operative duration and
               optimize patient outcomes. Planning typically starts with a complete history and physical to determine the
               anticipated defect and patient specific factors that will influence flap selection such as body habitus and
               prior surgery. Flap selection is also often drived by the surgeon’s prior experience and preferred donor sites.


               Certain flaps have reliable anatomy and require minimal preoperative planning. For example, a physical
               exam is adequate when planning to do a radial forearm, ulnar, lateral arm, or latissimus. However with the
               use of perforator-based flaps with variable anatomy such as the anterolateral thigh (ALT), thoracodorsal
               artery perforator (TDAP), and deep inferior epigastric perforator (DIEP) some surgeons find preoperative
               planning helpful. Studies have also shown decreased operative duration when preoperative perforator
               mapping is utilized . The use of various imaging modalities in perforator mapping may be valuable in
                                [3,4]
               cases where the skin paddle must be thinned or split. It can also be considered in cases where larger skin
               paddles are required, to assist with better centering the perforator within the skin paddle and capture its
               respective angiosome. Here we will discuss some imaging options for perforator mapping in the
               preoperative setting.

               Computer tomography angiography
               Head and neck surgeons commonly use computer tomography angiogram (CTA) for fibula flap planning to
               rule out vascular disease and anatomic variants in vascular supply to the foot. This also allows for perforator
                                                       [5]
               mapping when designing the fibula skin paddle . A lesser-used alternative to CTA for perforator mapping
               in the fibula free flap is magnetic resonance angiography (MRA) . In a comparative study, Rozen et al.
                                                                       [6]
                                                                                                         [7]
               found that CTA is able to identify perforators as small as 0.3 mm, smaller than the 1 mm perforators
               detectable by advancements in MRA technology. CTA is also commonly used in DIEP flap planning by
               breast reconstructive surgeons where its utility has been well documented. CTA for other types of perforator
               flaps are less commonly used by head and neck surgeons.


                        [8]
               Chen et al.  showed significantly decreased operative duration in ALT harvest by adopting preoperative
               CTA. Interestingly, they did not witness a significant difference in the number of perforators identified
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