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Table 1. Summary of clinical studies including cell-supplemented autologous fat grafting
Study Number of
Title Authors Year Results
design patients
Progenitor-enriched adipose tissue transplantation as rescue for breast implant Yoshimura et 2010 Prospective 15 No major complications or abnormalities on 12-month imaging. Surviving fat
complications al. [49] volume at 12 months was 155 ± 50 cc (right) and 143 ± 80 cc (left) following
grafting an initial mean of 264 cc
Cell-assisted lipotransfer for cosmetic breast augmentation: supportive use of Yoshimura et 2008 Prospective 40 Retained augmentation of 100 to 200 mL after a mean fat amount of 270 cc
adipose-derived stem/stromal cells al. [50] injected
Autologous cell-enriched fat grafting for breast augmentation Kamakura et al. 2011 Prospective 20 Increased circumferential breast measurement of 3.3 cm at 9 months with
[51]
75% patient satisfaction at that time
Prospective trial of adipose-derived regenerative cell (ADRC)-enriched fat Perez-Cano et 2012 Prospective 67 No major complications. Fifty patients reported satisfaction with treatment
grafting for partial mastectomy defects: the RESTORE-2 trial al. [52] at 12 months; investigators reported satisfaction with 57 patients. Blinded
radiographic assessment showed improved breast contour in 54 patients
A prospective study of the efficacy of cell-assisted lipotransfer with stromal Jeon et al. [54] 2020 Prospective 20 Higher fat retention in SVF enriched fat grafts at 6 and 12 months
vascular fraction to correct contour deformities of the autologous reconstructed
breast
[55]
Ex vivo-expanded autologous adipose tissue-derived stromal cells ensure Kolle et al. 2020 Prospective 16 Increased breast volume, retention, and enlargement at 4 months in patients
enhanced fat graft retention in breast augmentation: a randomized controlled treated with expanded-ASC enriched fat grafting
clinical trial
Cell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose- Yoshimura et 2008 Prospective 6 Patients with SVF augmented fat transfer had improved clinical outcome
derived stem cells al. [56] scores compared to patients without enriched fat
[57]
Clinical application of human adipose tissue-derived mesenchymal stem cells in Koh et al. 2012 Prospective 10 Patients receiving ASC enriched fat grafts showed decreased resorption at
progressive hemifacial atrophy (Parry-Romberg disease) with microfat grafting 15 months
techniques using 3-dimensional computed tomography and 3-dimensional
camera
[58]
Adipose-derived stromal vascular fraction cells and platelet-rich plasma: basic Gentile et al. 2014 Prospective 20 Improved retention of contour at 1 year with SVF-enhanced fat grafting to
and clinical evaluation for cell-based therapies in patients with scars on the face facial scars
[59]
Quantitative volumetric analysis of progressive hemifacial atrophy corrected using Chang et al. 2013 Prospective 20 Improved patient satisfaction and fat survival seen with SVF augmented fat
stromal vascular fraction-supplemented autologous fat grafts
[60]
The safety and efficacy of cell-assisted fat grafting to traditional fat grafting in the Sasaki 2015 Prospective 236 SVF fat supplementation to the midface led to increased fat retention at 12
anterior mid-face: an indirect assessment by 3D imaging months
[
Fat grafts supplemented with adipose-derived stromal cells in the rehabilitation of Tanikawa et al. 2013 Prospective 14 Fat supplementation with SVF led to increased fat retention at 6 months
61]
patients with craniofacial microsomia compared to control
Mechanical supplementation with the stromal vascular fraction yields improved Gontijo-de- 2017 Prospective 30 SVF fat enrichment showed increased retention via CT imaging at 12 months
[62
volume retention in facial lipotransfer: a 1-year comparative study Amorim et al. postoperatively after facial grafting
]
[63]
Stromal vascular fraction improves the durability of autologous fat temple Roshdy et al. 2022 Prospective 15 SVF fat enrichment increased fat volume retention at 6 months in bilateral
augmentation - a split-face randomized study using ultrasound biomicroscopy temporal fat grafting
Adipose tissue-derived stem cells: in vitro and in vivo analysis of a standard and Domenis et al. [ 2015 Prospective 36 SVF-enriched fat grafts demonstrated superior retention of thickness at six
40]
three commercially available cell-assisted lipotransfer techniques and 12 months
Breast reconstruction with enhanced stromal vascular fraction fat grafting: what is Gentile et al. [41] 2015 Prospective 50 Celution and fastem had the highest
the best method?