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Sharma et al. Neuroimmunol Neuroinflammation 2018;5:43 I http://dx.doi.org/10.20517/2347-8659.2018.51 Page 7 of 12

Organ System Symptoms

• Fever
• Malaise
• Anorexia
• Myalgias
Systemic
• Headaches Ataxia
• Altered mental status • Dysmetria
•
• Delirium • Tremor
• Hallucinations • Myoclonus
• Aphasia
Neurological • Apraxia • Seizures

• Acute kidney injury • Hypophosphatemia
• Hyponatremia Tumor lysis syndrome
• Hypokalemia •
Renal

• Transaminitis
• Hyperbilirubinemia
Hepato-billiary

• Nausea
• Emesis
• Diarrhea
Gastrointestinal

• Tachycardia • Decreased left ventricular ejection fraction
• Hypotension • Troponinemia
• Arrhythmias • QTprolongation
Cardiovascular

• Myalgias
• Weakness
• Creatine kinase elevation
Musculoskeletal

• Tachypnea
• Hypoxia
Pulmonary
• Anemia • Hypofibrinogenemia
• Thrombocytopenia • Prolonged activated partial thromboplastin time
• Neutropenia • Elevated D-dimer
• Lymphopenia • Disseminated intravascular coagulation
• B cell aplasia
Hematologic • Prolonged prothrombin time • Hemophagocytic lymphohistiocytosis

Figure 2. Toxicity from chimeric antigen receptor-T by organ system. Chimeric antigen receptor-T cell treatment has been found to result
in a number of toxicities throughout the body. Professional illustration by Ryan Stemen