Page 342 - Read Online

Page 14 of 14 Choi et al. Neuroimmunol Neuroinflammation 2018;5:42 I http://dx.doi.org/10.20517/2347-8659.2018.47

68. Meng Y, Carpentier AF, Chen L, Boisserie G, Simon JM, et al. Successful combination of local CpG-ODN and radiotherapy in
malignant glioma. Int J Cancer 2005;116:992-7.
69. Ursu R, Carpentier A, Metellus P, Lubrano V, Laigle-Donadey F, et al. Intracerebral injection of CpG oligonucleotide for patients with
de novo glioblastoma-A phase II multicentric, randomised study. Eur J Cancer. 2017;73:30-7.
70. Chiu TL, Wang MJ, Su CC. The treatment of glioblastoma multiforme through activation of microglia and TRAIL induced by rAAV2-
mediated IL-12 in a syngeneic rat model. J Biomed Sci 2012;19:45.
71. Chiu TL, Peng CW, Wang MJ. Enhanced anti-glioblastoma activity of microglia by AAV2-mediated IL-12 through TRAIL and
phagocytosis in vitro. Oncol Rep 2011;25:1373-80.
72. Zeiner PS, Preusse C, Blank AE, Zachskorn C, Baumgarten P, et al. MIF receptor CD74 is restricted to microglia/macrophages,
associated with a M1-polarized immune milieu and prolonged patient survival in gliomas. Brain Pathol 2015;25:491-504.
73. Waugh DJ, Wilson C. The interleukin-8 pathway in cancer. Clin Cancer Res 2008;14:6735-41.
74. Brat DJ, Bellail AC, Van Meir EG. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol
2005;7:122-33.
75. Infanger DW, Cho Y, Lopez BS, Mohanan S, Liu SC, et al. Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral
perivascular niche. Cancer Res 2013;73:7079-89.
76. Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, et al. CSF-1R inhibition alters macrophage polarization and blocks
glioma progression. Nat Med 2013;19:1264-72.
77. Yan D, Kowal J, Akkari L, Schuhmacher AJ, Huse JT, et al. Inhibition of colony stimulating factor-1 receptor abrogates
microenvironment-mediated therapeutic resistance in gliomas. Oncogene 2017;36:6049-58.
78. Quail DF, Bowman RL, Akkari L, Quick ML, Schuhmacher AJ, et al. The tumor microenvironment underlies acquired resistance to
CSF-1R inhibition in gliomas. Science 2016; doi: 10.1126/science.aad3018.
79. Feng X, Szulzewsky F, Yerevanian A, Chen Z, Heinzmann D, et al. Loss of CX3CR1 increases accumulation of inflammatory
monocytes and promotes gliomagenesis. Oncotarget 2015;6:15077-94.
80. Zhang J, Sarkar S, Cua R, Zhou Y, Hader W, et al. A dialog between glioma and microglia that promotes tumor invasiveness through the
CCL2/CCR2/interleukin-6 axis. Carcinogenesis 2012;33:312-9.
81. Li R, Li G, Deng L, Liu Q, Dai J, et al. IL-6 augments the invasiveness of U87MG human glioblastoma multiforme cells via up-
regulation of MMP-2 and fascin-1. Oncol Rep 2010;23:1553-9.
82. Wang H, Lathia JD, Wu Q, Wang J, Li Z, et al. Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth.
Stem Cells 2009;27:2393-404.
83. Markovic DS, Vinnakota K, van Rooijen N, Kiwit J, Synowitz M, et al. Minocycline reduces glioma expansion and invasion by
attenuating microglial MT1-MMP expression. Brain Behav Immun 2011;25:624-8.
84. Nikodemova M, Duncan ID, Watters JJ. Minocycline exerts inhibitory effects on multiple mitogen-activated protein kinases and
IkappaBalpha degradation in a stimulus-specific manner in microglia. J Neurochem 2006;96:314-23.
85. Umemura N, Saio M, Suwa T, Kitoh Y, Bai J, et al. Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed
monocytes/macrophages that bear M1- and M2-type characteristics. J Leukoc Biol 2008;83:1136-44.
86. Tchoghandjian A, Jennewein C, Eckhardt I, Rajalingam K, Fulda S. Identification of non-canonical NF-κB signaling as a critical
mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells. Cell Death Dis 2013; doi: 10.1038/cddis.2013.70.
87. Taetzsch T, Levesque S, McGraw C, Brookins S, Luqa R, et al. Redox regulation of NF-κB p50 and M1 polarization in microglia. Glia
2015;63:423-40.
88. Wu Y, Zhou BP. TNF-alpha/NF-kappaB/snail pathway in cancer cell migration and invasion. Br J Cancer 2010;102:639-44.
89. Hu F, Ku MC, Markovic D, a Dzaye OD, Lehnardt S, et al. Glioma-associated microglial MMP9 expression is upregulated by TLR2
signaling and sensitive to minocycline. Int J Cancer 2014;135:2569-78.
90. Vinnakota K, Hu F, Ku MC, Georgieva PB, Szulzewsky F, et al. Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP
expression and glioma expansion. Neuro Oncol 2013;15:1457-68.
91. Jacobs VL, Liu Y, De Leo JA. Propentofylline targets TROY, a novel microglial signaling pathway. PLoS One 2012; doi: 10.1371/
journal.pone.0037955.
92. Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev
Immunol 2007;7:41-51.
93. Takeda K, Clausen BE, Kaisho T, Tsujimura T, Terada N, et al. Enhanced Th1 activity and development of chronic enterocolitis in mice
devoid of Stat3 in macrophages and neutrophils. Immunity 1999;10:39-49.
94. Zhang L, Alizadeh D, Van Handel M, Kortylewski M, Yu H, et al. Stat3 inhibition activates tumor macrophages and abrogates glioma
growth in mice. Glia 2009;57:1458-67.
95. Lisi L, Laudati E, Navarra P, Dello Russo C. The mTOR kinase inhibitors polarize glioma-activated microglia to express a M1
phenotype. J Neuroinflammation 2014;11:125.
96. Hussain SF, Kong LY, Jordan J, Conrad C, Madden T, et al. A novel small molecule inhibitor of signal transducers and activators of
transcription 3 reverses immune tolerance in malignant glioma patients. Cancer Res 2007;67:9630-6.
97. Brandenburg S, Müller A, Turkowski K, Radev YT, Rot S, et al. Resident microglia rather than peripheral macrophages promote
vascularization in brain tumors and are source of alternative pro-angiogenic factors. Acta Neuropathol 2016;131:365-78.
98. Tabouret E, Tchoghandjian A, Denicolai E, Delfino C, Metellus P, et al. Recurrence of glioblastoma after radio-chemotherapy is
associated with an angiogenic switch to the CXCL12-CXCR4 pathway. Oncotarget 2015;6:11664-75.