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on glioma cells depends upon the expression of CARs   a platform for further genetic modifications and
           on their surface. The vector produced by the insertion   combination treatments. Since the first clinical trials
           of RGD peptide, named Ad-Δ24-RGD, can overcome     have assured its safety, it is important for the future
           this problem since it can directly bind to cell surface   research to seek for enhancements in its genome and
           integrins. [17]                                    combining agents that could refine its effect.

           Furthermore, a number of studies have focused on   REFERENCES
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           Another important aspect of oncolytic virotherapy      Seymour LW. Virotherapy of ovarian cancer with polymer‑cloaked
           is the induction of augmented antitumor immune         adenovirus retargeted to the epidermal growth factor receptor. Mol
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                                                                  Mitlianga P, Shi YX, Levin VA, Yung WK, Kyritsis AP. A mutant
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           CLINICAL TRIALS                                        effect in vivo. Oncogene 2000;19:2‑12.
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            2                                              Neuroimmunol Neuroinflammation | Volume 2 | Issue 1 | January 15, 2015
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