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Milluzzo et al. Metab Target Organ Damage 2024;4:5 https://dx.doi.org/10.20517/mtod.2023.43 Page 5 of 14

(Japan)
Alkyl agents +
Taxanes
Carboplatin + Case report of a 59-yo man NSCLC - Yes Retinal ischaemia After changing anticancer drugs, the soft [28]
paclitaxel (Japan) Soft exudates exudates and haemorrhages disappeared
Haemorrhages
Carboplatin + Case report of a 70-yo Cervix uteri No Retinal ischaemia Retinal signs disappeared after drugs [29]
paclitaxel woman Cotton wool spots cessation
(Egypt)
Alkyl agents + Topo
inhib
Cisplatin + Case report of a 4-yo and Retroperitoneal malignant mixed - No Retinal granular pigmentation Retinal and optic nerve signs were permanent [32]
etoposide 7-yo girls germ cell tumour and liver cancer Optic nerve pallor
(USA)
MAPK inhib
Pimasertib Prospective Cutaneous melanoma 100% Yes (not indicated the Sub-retinal fluid Retinal signs disappeared despite the [39]
(Netherlands) prevalence in the whole continuation of the drug
cohort)
Pimasertib Case report of a 26-yo Ovarian - No Outer retinal layer separation Retinal signs disappeared after drug cessation [37]
woman
(Canada)
Selumetinib Case report of a 13-yo girl Pilocytic astrocytoma - No Outer retinal layer separation Retinal signs disappeared after drug cessation [38]
and 6-yo boy
(USA)
Binimetinib Prospective Cutaneous/uveal melanoma 60%- No Subretinal fluid Retinal signs disappeared despite the [40]
(Netherlands) 77% continuation of the drug
Binimetinib Phase 1 study Various solid cancers 62% Not indicated Retinal detachment Retinal signs improved, in most of the cases, [41]
after stopping the drug
MAPK+BRAF inhib
Trametinib + Case report of a 39-yo Cutaneous melanoma - No Serious retinal detachments Permanent extensive extra-macula retinal [42]
dabrafenib woman Extra-macula retinal fibrosis fibrosis
(Spain)
Tyrosine-kinase
inhib
Imatinib Case report of a 62-yo man GIST - No Mild retinal haemorrhages Retinal signs disappeared after drug dose [43]
(USA) Neovascularization reduction
Imatinib Prospective Chronic myeloid leukemia 1%-2% Yes (not indicated the Retinal haemorrhages Retinal signs usually disappeared after drug [44]
(Italy) prevalence in the whole cessation
cohort)
VEGF inhib
Pazopanib