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Writing - review and editing: Vatlin AA, Pavshintsev VV, Mitkin NA, Maltseva ON, Utkina AS, Orekhov
AN

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Financial support and sponsorship
This work was supported by the RUDN University Scientific Projects Grant System (Project No.
202760-2-000).

Conflicts of interest
The authors declare that there are no conflicts of interest.

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Copyright
© The Author(s) 2026.

REFERENCES

1. Lin YJ, Anzaghe M, Schülke S. Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis. Cells.
2020;9:880. DOI PubMed PMC
2. Amaya-Amaya J, Rojas-Villarraga A, Mantilla RD, et al. Rheumatoid arthritis. In: Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al.,
editors. Autoimmunity: From Bench to Bedside. Bogota (Colombia): El Rosario University Press; 2013. Chapter 24. PubMed
3. Bullock J, Rizvi SAA, Saleh AM, et al. Rheumatoid arthritis: a brief overview of the treatment. Med Princ Pract. 2018;27:501-7. DOI
PubMed PMC
4. Radu AF, Bungau SG. Management of rheumatoid arthritis: an overview. Cells. 2021;10:2857. DOI PubMed PMC
5. Ben Mrid R, Bouchmaa N, Ainani H, El Fatimy R, Malka G, Mazini L. Anti-rheumatoid drugs advancements: new insights into the
molecular treatment of rheumatoid arthritis. Biomed Pharmacother. 2022;151:113126. DOI PubMed
6. Haschka J, Englbrecht M, Huebe A, et al. Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping
antirheumatic therapy: interim results from the prospective randomised controlled RETRO study. Ann Rheum Dis. 2016;75:45-51. DOI
PubMed
7. Frazzei G, Musters A, de Vries N, Tas SW, van Vollenhoven RF. Prevention of rheumatoid arthritis: a systematic literature review of
preventive strategies in at-risk individuals. Autoimmun Rev. 2023;22:103217. DOI PubMed
8. Wang Z, Huang J, Xie D, He D, Lu A, Liang C. Toward overcoming treatment failure in rheumatoid arthritis. Front Immunol.
2021;12:755844. DOI PubMed PMC
9. Fanouriakis A, Kostopoulou M, Andersen J, et al. EULAR recommendations for the management of systemic lupus erythematosus: 2023
update. Ann Rheum Dis. 2024;83:15-29. DOI PubMed
10. Khader Y, Beran A, Ghazaleh S, Lee-Smith W, Altorok N. Predictors of remission in rheumatoid arthritis patients treated with biologics:
a systematic review and meta-analysis. Clin Rheumatol. 2022;41:3615-27. DOI PubMed PMC
11. Ajeganova S, Huizinga T. Sustained remission in rheumatoid arthritis: latest evidence and clinical considerations. Ther Adv
Musculoskelet Dis. 2017;9:249-62. DOI PubMed PMC
12. Deane KD, Norris JM, Holers VM. Preclinical rheumatoid arthritis: identification, evaluation, and future directions for investigation.
Rheum Dis Clin North Am. 2010;36:213-41. DOI PubMed PMC
13. Sokolova MV, Schett G, Steffen U. Autoantibodies in rheumatoid arthritis: historical background and novel findings. Clin Rev Allergy
Immunol. 2022;63:138-51. DOI PubMed PMC
14. Holers VM, Demoruelle KM, Buckner JH, et al. Distinct mucosal endotypes as initiators and drivers of rheumatoid arthritis. Nat Rev
Rheumatol. 2024;20:601-13. DOI PubMed PMC
15. Sanmartí R, Frade-Sosa B, Ponce A. The so-called pre-clinical rheumatoid arthritis: doubts, challenges, and opportunities. J Clin Med.
2024;13:6387. DOI PubMed PMC