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Ethical approval and consent to participate
Isolation of Akkermansia strains from the stool of RCC patients at Duke University Hospital (IRB protocol
Pro00076768) and from the stool of patients with amyotrophic lateral sclerosis (People with ALS, PALS)
patients at Duke University Hospital (IRB protocol Pro00108282) was both approved by the Duke
Institutional Review Board. Signed informed consent was obtained from individuals enrolled in these
studies, indicating awareness that their stool would be used for scientific research.
Consent for publication
Not applicable.
Copyright
© The Author(s) 2024.
REFERENCES
1. Derrien M, Vaughan EE, Plugge CM, de Vos WM. Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading
bacterium. Int J Syst Evol Microbiol 2004;54:1469-76. DOI PubMed
2. Derrien M, Collado MC, Ben-Amor K, Salminen S, de Vos WM. The Mucin degrader Akkermansia muciniphila is an abundant
resident of the human intestinal tract. Appl Environ Microbiol 2008;74:1646-8. DOI PubMed PMC
3. Everard A, Belzer C, Geurts L, et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced
obesity. Proc Natl Acad Sci U S A 2013;110:9066-71. DOI PubMed PMC
4. Lukovac S, Belzer C, Pellis L, et al. Differential modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of host
peripheral lipid metabolism and histone acetylation in mouse gut organoids. mBio 2014;5:e01438-14. DOI PubMed PMC
5. Plovier H, Everard A, Druart C, et al. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium
improves metabolism in obese and diabetic mice. Nat Med 2017;23:107-13. DOI PubMed
6. Routy B, Le Chatelier E, Derosa L, et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
Science 2018;359:91-7. DOI PubMed
7. Schneeberger M, Everard A, Gómez-Valadés AG, et al. Akkermansia muciniphila inversely correlates with the onset of inflammation,
altered adipose tissue metabolism and metabolic disorders during obesity in mice. Sci Rep 2015;5:16643. DOI PubMed PMC
8. Earley H, Lennon G, Balfe Á, Coffey JC, Winter DC, O’Connell PR. The abundance of Akkermansia muciniphila and its relationship
with sulphated colonic mucins in health and ulcerative colitis. Sci Rep 2019;9:15683. DOI PubMed PMC
9. Olson CA, Vuong HE, Yano JM, Liang QY, Nusbaum DJ, Hsiao EY. The gut microbiota mediates the anti-seizure effects of the
ketogenic diet. Cell 2018;174:497. DOI PubMed PMC
10. Blacher E, Bashiardes S, Shapiro H, et al. Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature
2019;572:474-80. DOI PubMed
11. Cox LM, Maghzi AH, Liu S, et al. Gut microbiome in progressive multiple sclerosis. Ann Neurol 2021;89:1195-211. DOI PubMed
PMC
12. Salazar N, Arboleya S, Fernández-Navarro T, de Los Reyes-Gavilán CG, Gonzalez S, Gueimonde M. Age-associated changes in gut
microbiota and dietary components related with the immune system in adulthood and old age: a cross-sectional study. Nutrients
2019;11:1765. DOI PubMed PMC
13. Perraudeau F, McMurdie P, Bullard J, et al. Improvements to postprandial glucose control in subjects with type 2 diabetes: a
multicenter, double blind, randomized placebo-controlled trial of a novel probiotic formulation. BMJ Open Diabetes Res Care
2020;8:e001319. DOI PubMed PMC
14. Cani PD, Depommier C, Derrien M, Everard A, de Vos WM. Akkermansia muciniphila: paradigm for next-generation beneficial
microorganisms. Nat Rev Gastroenterol Hepatol 2022;19:625-37. DOI PubMed
15. Depommier C, Everard A, Druart C, et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers:
a proof-of-concept exploratory study. Nat Med 2019;25:1096-103. DOI PubMed PMC
16. Spreafico A, Heirali AA, Araujo DV, et al. First-in-class Microbial Ecosystem Therapeutic 4 (MET4) in combination with immune
checkpoint inhibitors in patients with advanced solid tumors (MET4-IO trial). Ann Oncol 2023;34:520-30. DOI PubMed
17. Derrien M, Van Baarlen P, Hooiveld G, Norin E, Müller M, de Vos WM. Modulation of mucosal immune response, tolerance, and
proliferation in mice colonized by the mucin-degrader Akkermansia muciniphila. Front Microbiol 2011;2:166. DOI PubMed PMC
18. Collado MC, Derrien M, Isolauri E, de Vos WM, Salminen S. Intestinal integrity and Akkermansia muciniphila, a mucin-degrading
member of the intestinal microbiota present in infants, adults, and the elderly. Appl Environ Microbiol 2007;73:7767-70. DOI
PubMed PMC

