Page 80 - Read Online

Page 32 of 35 Boyajian et al. Microbiome Res Rep 2024;3:29 https://dx.doi.org/10.20517/mrr.2024.05

150. Mohammed I, Hollenberg MD, Ding H, Triggle CR. A critical review of the evidence that metformin is a putative anti-aging drug
that enhances healthspan and extends lifespan. Front Endocrinol 2021;12:718942. DOI PubMed PMC
151. Campbell JM, Bellman SM, Stephenson MD, Lisy K. Metformin reduces all-cause mortality and diseases of ageing independent of its
effect on diabetes control: a systematic review and meta-analysis. Ageing Res Rev 2017;40:31-44. DOI PubMed
152. U.S. Food and Drug Administration. GLUCOPHAGE® (metformin hydrochloride) tablets. Available from: https://www.accessdata.
fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf. [Last accessed on 15 May 2024].
153. LaMoia TE, Shulman GI. Cellular and molecular mechanisms of metformin action. Endocr Rev 2021;42:77-96. DOI PubMed PMC
154. Kulkarni AS, Brutsaert EF, Anghel V, et al. Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and
subcutaneous adipose tissues of older adults. Aging Cell 2018;17:e12723. DOI PubMed PMC
155. U.S. Food and Drug Administration. Rapamune (sirolimus) Label. Highlights of prescribing information. Available from: https://
www.accessdata.fda.gov/drugsatfda_docs/label/2017/021083s059,021110s076lbl.pdf. [Last accessed on 15 May 2024].
156. Juricic P, Lu YX, Leech T, et al. Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently
increased intestinal autophagy. Nat Aging 2022;2:824-36. DOI PubMed PMC
157. Kulkarni AS, Aleksic S, Berger DM, Sierra F, Kuchel GA, Barzilai N. Geroscience-guided repurposing of FDA-approved drugs to
target aging: A proposed process and prioritization. Aging Cell 2022;21:e13596. DOI PubMed PMC
158. Ershad M, Naji A, Vearrier D. N-acetylcysteine. Treasure island (FL): StatPearls Publishing; 2024. PubMed
159. Sohouli MH, Eslamian G, Malekpour Alamdari N, et al. Effects of N-acetylcysteine on aging cell and obesity complications in obese
adults: a randomized, double-blind clinical trial. Front Nutr 2023;10:1237869. DOI PubMed PMC
TM
160. U.S. Food and Drug Administration. Sprycel (dasatinib) tablets. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/
nda/2006/021986s000_Sprycel__PRNTLBL.pdf. [Last accessed on 15 May 2024].
161. Zhang L, Pitcher LE, Yousefzadeh MJ, Niedernhofer LJ, Robbins PD, Zhu Y. Cellular senescence: a key therapeutic target in aging
and diseases. J Clin Invest 2022;132:e158450. DOI PubMed PMC
162. Scarpellini E, Rinninella E, Basilico M, et al. From pre- and probiotics to post-biotics: a narrative review. Int J Environ Res Public
Health 2021;19:37. DOI PubMed PMC
163. Slavin J. Fiber and prebiotics: mechanisms and health benefits. Nutrients 2013;5:1417-35. DOI PubMed PMC
164. Green M, Arora K, Prakash S. Microbial medicine: prebiotic and probiotic functional foods to target obesity and metabolic syndrome.
Int J Mol Sci 2020;21:2890. DOI PubMed PMC
165. Davani-Davari D, Negahdaripour M, Karimzadeh I, et al. Prebiotics: definition, types, sources, mechanisms, and clinical applications.
Foods 2019;8:92. DOI PubMed PMC
166. Canfora EE, van der Beek CM, Hermes GDA, et al. Supplementation of diet with galacto-oligosaccharides increases bifidobacteria,
but not insulin sensitivity, in obese prediabetic individuals. Gastroenterology 2017;153:87-97.e3. DOI PubMed
167. Arnold JW, Roach J, Fabela S, et al. The pleiotropic effects of prebiotic galacto-oligosaccharides on the aging gut. Microbiome
2021;9:31. DOI PubMed PMC
168. Qiang X, Yonglie C, Qianbing W. Health benefit application of functional oligosaccharides. Carbohydr Polym 2009;77:435-41. DOI
169. Ma C, Yang K, Wang Y, Dai X. Anti-aging effect of agar oligosaccharide on male drosophila melanogaster and its preliminary
mechanism. Mar Drugs 2019;17:632. DOI PubMed PMC
170. D’Andrea G. Quercetin: a flavonol with multifaceted therapeutic applications? Fitoterapia 2015;106:256-71. DOI PubMed
171. Jung CH, Cho I, Ahn J, Jeon TI, Ha TY. Quercetin reduces high-fat diet-induced fat accumulation in the liver by regulating lipid
metabolism genes. Phytother Res 2013;27:139-43. DOI PubMed
172. Cui Z, Zhao X, Amevor FK, et al. Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism.
Front Immunol 2022;13:943321. DOI PubMed PMC
173. Saccon TD, Nagpal R, Yadav H, et al. Senolytic combination of dasatinib and quercetin alleviates intestinal senescence and
inflammation and modulates the gut microbiome in aged mice. J Gerontol A Biol Sci Med Sci 2021;76:1895-905. DOI PubMed
PMC
174. Gonzales MM, Garbarino VR, Marques Zilli E, et al. Senolytic therapy to modulate the progression of Alzheimer’s disease (SToMP-
AD): a pilot clinical trial. J Prev Alzheimers Dis 2022;9:22-9. DOI PubMed PMC
175. Zhao L, Zhu X, Xia M, et al. Quercetin ameliorates gut microbiota dysbiosis that drives hypothalamic damage and hepatic
lipogenesis in monosodium glutamate-induced abdominal obesity. Front Nutr 2021;8:671353. DOI PubMed PMC
176. Shi T, Bian X, Yao Z, Wang Y, Gao W, Guo C. Quercetin improves gut dysbiosis in antibiotic-treated mice. Food Funct
2020;11:8003-13. DOI
177. Yuan H, Li Y, Ling F, et al. The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism,
reducing inflammation and oxidative stress in high-fat diet-fed obese rats. Aging Cell 2020;19:e13199. DOI PubMed PMC
178. Huang LH, Liu CY, Wang LY, Huang CJ, Hsu CH. Effects of green tea extract on overweight and obese women with high levels of
low density-lipoprotein-cholesterol (LDL-C): a randomised, double-blind, and cross-over placebo-controlled clinical trial. BMC
Complement Altern Med 2018;18:294. DOI PubMed PMC
179. D'Amico D, Olmer M, Fouassier AM, et al. Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates
pain in osteoarthritis. Aging Cell 2022;21:e13662. DOI PubMed PMC
180. Kong S, Huang X, Cao H, et al. Anti-obesity effects of galacto-oligosaccharides in obese rats. Eur J Pharmacol 2022;917:174728.
DOI