Page 103 - Read Online
P. 103

Gotoh et al. Microbiome Res Rep 2023;2:20  https://dx.doi.org/10.20517/mrr.2023.14  Page 15 of 17

               Conflicts of interest
               Employment of Sakanaka M at Kyoto University is in part supported by Morinaga Milk Industry Co., Ltd.
               The other authors declare no conflicts of interest.


               Ethical approval and consent to participate
               Not applicable.

               Consent for publication
               Not applicable.

               Copyright
               © The Author(s) 2023.

               REFERENCES
               1.       Stewart CJ, Ajami NJ, O’Brien JL, et al. Temporal development of the gut microbiome in early childhood from the TEDDY study.
                   Nature 2018;562:583-8.  DOI  PubMed  PMC
               2.       Sakanaka M, Hansen ME, Gotoh A, et al. Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant
                   symbiosis. Sci Adv 2019;5:eaaw7696.  DOI  PubMed  PMC
               3.       Asakuma S, Hatakeyama E, Urashima T, et al. Physiology of consumption of human milk oligosaccharides by infant gut-associated
                   bifidobacteria. J Biol Chem 2011;286:34583-92.  DOI  PubMed  PMC
               4.       Sakanaka M, Gotoh A, Yoshida K, et al. Varied pathways of infant gut-associated Bifidobacterium to assimilate human milk
                   oligosaccharides: prevalence of the gene set and its correlation with bifidobacteria-rich microbiota formation. Nutrients 2019;12:71.
                   DOI  PubMed  PMC
               5.       Yamada C, Gotoh A, Sakanaka M, et al. Molecular insight into evolution of symbiosis between breast-fed infants and a member of the
                   human gut microbiome Bifidobacterium longum. Cell Chem Biol 2017;24:515-524.e5.  DOI
               6.       Ojima MN, Jiang L, Arzamasov AA, et al. Priority effects shape the structure of infant-type Bifidobacterium communities on human
                   milk oligosaccharides. ISME J 2022;16:2265-79.  DOI  PubMed  PMC
               7.       Engfer MB, Stahl B, Finke B, Sawatzki G, Daniel H. Human milk oligosaccharides are resistant to enzymatic hydrolysis in the upper
                   gastrointestinal tract. Am J Clin Nutr 2000;71:1589-96.  DOI  PubMed
               8.       Urashima T, Asakuma S, Leo F, Fukuda K, Messer M, Oftedal OT. The predominance of type I oligosaccharides is a feature specific
                   to human breast milk. Adv Nutr 2012;3:473S-82S.  DOI  PubMed  PMC
               9.       Katayama T. Host-derived glycans serve as selected nutrients for the gut microbe: human milk oligosaccharides and bifidobacteria.
                   Biosci Biotechnol Biochem 2016;80:621-32.  DOI  PubMed
               10.      Garrido D, Kim JH, German JB, Raybould HE, Mills DA. Oligosaccharide binding proteins from Bifidobacterium longum subsp.
                   infantis reveal a preference for host glycans. PLoS One 2011;6:e17315.  DOI  PubMed  PMC
               11.     Yoshida E, Sakurama H, Kiyohara M, et al. Bifidobacterium longum subsp. infantis uses two different β-galactosidases for selectively
                   degrading type-1 and type-2 human milk oligosaccharides. Glycobiology 2022;22:361-8.  DOI
               12.      Viborg AH, Katayama T, Abou Hachem M, et al. Distinct substrate specificities of three glycoside hydrolase family 42 β-
                   galactosidases from Bifidobacterium longum subsp. infantis ATCC 15697. Glycobiology 2014;24:208-16.  DOI  PubMed
               13.      James  K,  Motherway  MO,  Bottacini  F,  van  Sinderen  D.  Bifidobacterium  breve  UCC2003  metabolises  the  human  milk
                   oligosaccharides lacto-N-tetraose and lacto-N-neo-tetraose through overlapping, yet distinct pathways. Sci Rep 2016;6:38560.  DOI
                   PubMed  PMC
               14.      O’ Connell Motherway M, Zomer A, Leahy SC, et al. Functional genome analysis of Bifidobacterium breve UCC2003 reveals type
                   IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor. Proc Natl Acad Sci U S A 2011;108:11217-22.
                   DOI  PubMed  PMC
               15.      Wada J, Ando T, Kiyohara M, et al. Bifidobacterium bifidum lacto-N-biosidase, a critical enzyme for the degradation of human milk
                   oligosaccharides with a type 1 structure. Appl Environ Microbiol 2008;74:3996-4004.  DOI  PubMed  PMC
               16.      Hattie M, Ito T, Debowski AW, et al. Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and
                   structural analysis. Chem Commun 2015;51:15008-11.  DOI
               17.      Sakurama H, Kiyohara M, Wada J, et al. Lacto-N-biosidase encoded by a novel gene of Bifidobacterium longum subspecies longum
                   shows unique substrate specificity and requires a designated chaperone for its active expression. J Biol Chem 2013;288:25194-206.
                   DOI  PubMed  PMC
               18.      Gotoh A, Katoh T, Sugiyama Y, et al. Novel substrate specificities of two lacto-N-biosidases towards β-linked galacto-N-biose-
                   containing oligosaccharides of globo H, Gb5, and GA1. Carbohydr Res 2015;408:18-24.  DOI  PubMed
               19.      Suzuki R, Wada J, Katayama T, et al. Structural and thermodynamic analyses of solute-binding Protein from Bifidobacterium longum
                   specific for core 1 disaccharide and lacto-N-biose I. J Biol Chem 2008;283:13165-73.  DOI
               20.      Kitaoka M. Bifidobacterial enzymes involved in the metabolism of human milk oligosaccharides. Adv Nutr 2012;3:422S-9S.  DOI
   98   99   100   101   102   103   104   105   106   107   108