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Table 1. Most relevant manuscripts organized by topic
Author Year Journal Manuscript type Comments
Kristo et al. [6] 2019 Obesity Surg Retrospective Testing and GERD in the obese
Patti et al. [12] 1997 Surg Clin North Am Lit Review GERD
Ayazi et al. [14] 2009 Gastrintest Surg Retrospective Obesity and GERD
Braghetto et al. [3] 2012 Obes Surg Prospective RYGB and GERD/Barrett’s
Ronkainen et al. [22] 2011 Am J Gastroenterol Prospective Barrett’s endoscopy
Akiyama et al. [23] 2009 BMC Gastroenterol Retrospective Visceral obesity/Barrett’s
Wood et al. [24] 2008 Keio J Med Literature review Barrett’s Esophagus
Corley et al. [25] 2007 Gastroenterology Case control Obesity and Barrett’s
Rossi et al. [27] 2006 Ann Surg Retrospective Nissen vs. medication Barrett’s
Parrilla et al. [28] 2003 Ann Surg RCT Barrett’s, surg vs. medicine
Chang et al. [29] 2007 Ann Surg System Rev Barrett’s medical management
Spechler et al. [33] 2014 Dig Dis Literature review Barrett’s and surgery
Adil et al. [34] 2019 Obes Surg System Rev/Meta-A RYGB effects on Barrett’s
Braghetto et al. [35] 2010 Obes Surg Prospective Manometry after LSG
Genco et al. [36] 2007 Surg Obes Rel Dis Prospective GERD/Barrett’s - Bariatric Surg
Soricelli et al. [37] 2018 Surg Obes Rel Dis Prospective GERD/Barrett’s - Bariatric Surg
Sebastianelli et al. [38] 2019 Obes Surg Prospective Endoscopy, Bariatric Surg
Felsenreich et al. [39] 2017 Obes Surg Prospective GERD/Barrett’s Bariatric Surg
Saino et al. [46] 2015 J Laparoendosc Adv Surg Tech Prosp/Multicenter LINX
Ganz et al. [47] 2016 Clin Gastroenterol Hepatol Retrospective LINX
Perez et al. [48] 2001 Surg Endosc Retrospective Obesity and antireflux surg
Morgenthal et al. [49] 2007 Surg Endosc Retrospective Obesity and antireflux surg
Kellogg et al. [50] 2006 Surg Obes Rel Dis Retrospective Failed antireflux conv to RYGB
Gagner et al. [52] 2013 Obes Surg Review LSG consensus
Frezza et al. [53] 2002 Surg Endosc Retrospective GERD symptoms after RYGB
Schietroma et al. [56] 2017 J Obes Retrospective GERD/Obesity surgery outcomes
Chiu et al .[57] 2011 Surg Obes Relat Dis Retrospective Bariatric Surgery and GERD
DuPree et al. [58] 2014 JAMA Surg Retrospective Bariatric Surgery and GERD
Himpens et al. [59] 2010 Ann Surg Retrospective LSG outcomes
Oor et al. [60] 2016 Am J Surg System Rev/Meta-A LSG and GERD
Gu et al. [61] 2019 Obes Surg System Rev/Meta-A Bariatric Surgery and GERD
Singh et al. [63] 2017 Obes Surg System Rev/Meta-A Bariatric Surgery, ERAS
Thorell et al. [64] 2016 World J Surg Guidelines Bariatric Surgery, ERAS
RYGB: roux-en-Y gastric bypass; GERD: gastroesophageal reflux disease; LSG: laparoscopic sleeve gastrectomy; ERAS: enhanced recovery
after surgery; LINX: magnetic sphincter augmentation reflux management system

frequently reported complication among surgeons surveyed at the Fourth International Consensus Summit
[52]
on Sleeve Gastrectomy . In a review paper drafted by the Society of American Gastrointestinal and
Endoscopic Surgeons Foregut Task Force, the LRYGB was identified as the treatment of choice for GERD
[53]
in obese patients. Authors such as Frezza et al. showed significant improvement of GERD symptoms
after offering LRYGB. His cohort of 152 obese patients with GERD had a substantial decrease in the use of
antiacid medication by 6 months after surgery. Along these lines, De Groote’s systematic review of bariatric
surgery and GERD compared various bariatric procedures and found that LRYGB was associated with a
notable decrease in GERD. They also analyzed outcomes of the LRYGB compared to lifestyle modifications
only, and the former group had better alleviation of GERD symptoms [54-56] .

In contrast to the outcomes seen after LRYGB in GERD patients, there are conflicting data surrounding
the relationship between GERD and LSG. In 2011, a systematic review of studies reporting post-LSG
[57]
GERD rates found no agreement was achieved . Seven of the studies that were included showed reduced
prevalence of GERD after LSG, while four found an increase in GERD. An important limitation of
many of these publications is the use of subjective symptoms to confer a diagnosis of GERD rather than
objective diagnostic exams. Furthermore, different follow up times and definitions of GERD among these
studies made it difficult to make conclusions. In a retrospective review including 4832 bariatric surgery