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Table 1. Main reports concerning short-term outcomes after lobectomy performed by thoracotomy or a minimally invasive
approach as VATS or RATS for a NSCLC in studies used for this article
Ref. Population study Outcomes Results
[13]
Ng et al. Comparison of multiport and VATS vs. Open
uniport VATS and RATS 145 Nodal upstaging OR 0.71 (95%CI 0.58-0.87) P < 0.001
studies, 369,793 patients Complications OR 0.64 (95%CI 0.59-0.71) P < 0.001
Comparison of VATS to 90-day mortality OR 0.78 (95%CI 0.56-1.07) P = 0.12
Open: 115 studies Length of hospital stay -1.9 d (95%CI -2.25 to -1.54) P < 0.001
5-year OS OR 1.35 (95%CI 1.17-1.56) P < 0.0001
5-year DFS OR 1.15 (95%CI 0.94-1.4) P = 0.18
VATS vs. RATS
Nodal upstaging OR 1.02 (95%CI 0.85-1.22) P = 0.87
Complications OR 1.28 (95%CI 0.75-2.17) P = 0.37
30-day mortality OR 1.04 (95%CI 0.73-1.47) P = 0.85
Length of hospital stay -0.16 d (95%CI -0.81 to -0.48) P = 0.62
5-year OS OR 0.79 (95%CI 0.47-1.33) P = 0.38
5-year DFS OR 0.71 (95%CI 0.44-1.14) P = 0.16
O’Sullivan et al. [14] Comparison of short-term RATS vs. Open
outcomes after lobectomy Complications OR 0.67 (95%CI 0.58-0.76) P < 0.00001
performed by Open. VATS or 30-day mortality 0.53 (95%CI 0.33-0.85) P = 0.08
RATS 112,356 patients Length of hospital stay WMD -1.4 (95%CI -1.96 to -0.85) P < 0.00001
Operative time WMD 65.56 (95%CI 53.66-77.46) P < 0.00001
RATS vs. VATS
30-day mortality OR 0.61 (95%CI 0.45-0.83) P = 0.001
Operative time WMD 4.98 (95%CI 2.61-7.36) P < 0.001
Adams et al. [29] Comparison of short-term RATS vs. Open
outcomes after a lobectomy Operative time 241 min vs. 175 min, P < 0.001
RATS to VATS and Open in a Postoperative blood transfusion 0.9% vs. 7.8%, P = 0.002 in % of patient
national Database Air leak > 5 days 5.2% vs. 10.8%, P = 0.05
n = 116 RATS Chest tube duration 3.2 days vs. 4.8 days, P < 0.001
n = 4612 VATS Length of hospital stay 4.7 days vs. 7.3 days, P < 0.001 in median
n = 5913 Open 30-day mortality 0% vs. 2.2%, P = 0.18
RATS vs. VATS
Operative time 241 min vs. 179 min, P < 0.001
Postoperative blood transfusion 0.9% vs. 3.8%, P = 0.13 in % of patient
Air leak > 5 days 5.2% vs. 8.9%, P = 0.17
Chest tube duration 3.2 days vs. 3.7 days, P = 0.18
Length of hospital stay 4.7 days vs. 5.3 days, P = 0.07
30-day mortality 0% vs. 1%, P = 0.63
Agzarian et al. [30] Comparison of short-term RATS vs. Open
outcomes after a lobectomy Operative time WMD 40.10 (95%CI -50.76 to -130.96) P = 0.39
RATS to VATS and Open 20 Length of hospital stay -1.97 days (95%CI -4.05 to -0.1) P = 0.06 in median
articles RATS vs. VATS
Operative time WMD 64.28 (95%CI -50.35 to -178.91) P = 0.27
Length of hospital stay -0.68 days (95%CI -1.52 to -0.16) P = 0.11
Kent et al. [15] Comparison of short-term RATS vs. Open
outcomes after a lobectomy Complication rate 43.8% vs. 54.1%, P = 0.003
RATS to VATS and Open in a Mortality rate 0.2% vs. 2%, P = 0.016
national database Length of hospital stay 5.9 days vs. 8.2 days, P < 0.0001 in median
n = 411 RATS RATS vs. VATS
n = 1233 VATS Complication rate 43.8% vs. 45.3%, P = 0.674
n = 1233 Open for Mortality 0.2% vs. 1.1%, P = 0.122
propensity-matched analysis Length of stay 5.9 days vs. 6.3 days, P = 0.454
Rajaram et al. [31] Comparison of short-term RATS vs. Open
outcomes after a lobectomy Length of hospital stay 6.1 days vs. 5.7 days, P < 0.001 in median
RATS to VATS and Open in a 90-day Mortality 3% vs. 3.4%, P = 0.097
national database 30-day unplanned readmission 4.1% vs. 4%, P = 0.81
n = 3238 to 3689 RATS RATS vs. VATS
n = 3401 to 3689 VATS Length of hospital stay 6.1 days vs. 5.9 days, P = 0.019 in median
n = 3405 to 3689 Open for 90-day Mortality 3% vs. 2.8%, P = 0.877
propensity-matched analysis 30-day unplanned readmission 4.1% vs. 4.6%, P = 0.258
Cao et al. [32] Comparison of short and RATS vs. Open
long term outcomes after a Complication rate RR 0.77 (95%CI 0.54-1.09) P = 0.14
lobectomy RATS and VATS n Length of hospital stay Shorter in RATS group P < 0.05
= 941 patients
For meta-analysis for short-
term outcomes n = 160 RATS
and n = 372 Open