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Author Instructions

            Brief        Brief communications are timely, peer-  1500   Unstructured abstract.   3-6   The brief
            Communication reviewed, and short (2-4 journal pages).  max  No more than 150 words. keywords communication is a
                         These may be used to report new                                   one body text with
                         developments, significant advances,                               maximum 4 items
                         and novel aspects of experimental and                             (figures and tables) and
                         theoretical methods and techniques                                12 references.
                         which are relevant for scientific
                         investigations within the journal scope.

           2.3 Manuscript Structure
           2.3.1 Front Matter
           2.3.1.1 Title
           The title of the manuscript should be concise, specific and relevant, with no more than 16 words if possible. When gene or
           protein names are included, the abbreviated name rather than full name should be used.

           2.3.1.2 Authors and Affiliations
           Authors’ full names should be listed. The initials of middle names can be provided. Institutional addresses and email
           addresses for all authors should be listed. At least one author should be designated as corresponding author. In addition,
           corresponding authors are suggested to provide their Open Researcher and Contributor ID upon submission. Please note
           that any change to authorship is not allowed after manuscript acceptance.

           2.3.1.3 Abstract
           Original research, systematic reviews, and meta-analyses require structured abstracts. The abstract should provide the
           context or background for the study and should state the study’s purpose, basic procedures (selection of study participants,
           settings, measurements, analytical methods), main findings (giving specific effect sizes and their statistical and clinical
           significance,  if  possible),  and  principal  conclusions.  It  should  emphasize  new  and  important  aspects  of  the  study  or
           observations, note important limitations, and not overinterpret findings. Clinical trial abstracts should include items that the
           CONSORT group has identified as essential. It is not allowed to contain results which are not presented and substantiated in
           the manuscript, or exaggerate the main conclusions. Citations should not be included in the abstract.

           2.3.1.4 Graphical Abstract
           The graphical abstract is essential as this can catch first view of your publication by readers. We request the authors submit
           an eye-catching figure during the revision stage. It should summarize the content of the article in a concise graphical
           form. It is recommended to use it because this can make online articles get more attention. The graphic abstract should be
           submitted as a separate document in the online submission system along with the revised version. Please provide an image
           with a minimum of 730 × 1,228 pixels (h × w) or proportionally more. The image should be readable at a size of 7 × 12 cm
           using a regular screen resolution of 96 dpi. Preferred file types: TIFF, PSD, AI, JPG, JPEG, EPS, PNG, ZIP and PDF files.
           2.3.1.5 Keywords
           Three to eight keywords should be provided, which are specific to the article, yet reasonably common within the subject
           discipline.

           2.3.2 Main Text
           Manuscripts of different types are structured with different sections of content. Please refer to Types of Manuscripts to
           make sure which sections should be included in the manuscripts.


           2.3.2.1 Introduction
           Provide a context or background for the study (that is, the nature of the problem and its significance). State the specific
           purpose or research objective of, or hypothesis tested by, the study or observation. Cite only directly pertinent references,
           and do not include data or conclusions from the work being reported.
           2.3.2.2 Methods
           The guiding principle of the Methods section should be clarity about how and why a study was done in a particular way. The
           Methods section should aim to be sufficiently detailed such that others with access to the data would be able to reproduce
           the results. In general, the section should include only information that was available at the time the plan or protocol for
           the study was being written; all information obtained during the study belongs in the Results section. If an organization
           was paid or otherwise contracted to help conduct the research (examples include data collection and management), then
           this should be detailed in the methods. The Methods section should include a statement indicating that the research was
           approved by an independent local, regional or national review body (e.g., ethics committee, institutional review board). If
           doubt exists whether the research was conducted in accordance with the Helsinki Declaration, the authors must explain

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