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Page 144 Shad. J Transl Genet Genom 2023;7:141-65 https://dx.doi.org/10.20517/jtgg.2023.11

Table 1. Significant genetic predictors of clozapine-induced agranulocytosis

Controls
CIA cases with CIA cases without Controls with
Reference Ethnicity Haplotype without Specificity Sensitivity OR P-value
haplotype haplotype haplotype
haplotype
Lieberman et al., Mainly Jewish (22/31) HLA-B38 5 0 4 13 100% 55% 16.25 0.005
[39]
1990 HLAB38-DR4-DQw3 5 0 2 15 100% 71% 37.5 0.008
[40]
Corzo et al., 1995 Jewish HSP-70 9.0-A 16 8 10 44 81% 62% 8.8 0.0001
Non-Jewish HSP-70 9.0-A 19 21 6 26 81% 47% 3.92 0.01
[41]
Yunis et al., 1995 Ashkenazi Jewish HLA-B38 14 1 7 25 96% 67% 50.0. < 0.0001
HLA-DR4 14 1 12 20 95% 54% 23.3
HLA-B38, DR4, DQw3 13 2 6 26 93% 68% 28.2 0.0004
< 0.0001

HLA-DRB1*0402 11 13 6 48 79% 46% 5.7 0.002
HLA-DQB1*0302 11 13 8 46 78% 58% 4.9 0.008
HLA-DQA1*0301 0 24 18 36 60% 0.0% 12.0 0.008
HLA-DRB1*11 0 24 13 41 63% 0.0% 7.6 0.007
HLA-DRB4*0101 10 14 6 48 11% 42% 5.7 0.005
HLA_DQB1*0302
HLA-DQA1*0301
Non-Jewish -HLA-DR2 17 8 5 24 75% 62% 4.5 0.01
-HLA-DR2, DQw1 14 11 4 15 58% 78% 4.8 0.03
-HLA-B7, DR2, DQw1 6 19 0 19 50% 100% 6.0 0.03
[42]
Turbay et al., 1997 Non-Jewish HSP-70 9.0-A 19 21 6 26 81% 47% 3.92 0.01
Non-Jewish European HLA-DQA1*0102 14 26 4 28 52% 78% 3.77 0.03
TNFb4 29 13 6 24 65% 83% 8.92 0.0005
TNFb5 8 34 22 8 19% 27% 0.08 0.0005
[43]
Amar et al., 1998 Jewish & Non-Jewish HLA-DQB1*0201 5 5 7 6 55% 42% 0.86 0.03
Valevski et al., Israeli Jewish HLA-B38 5 5 7 50 91% 42% 10.01 0.04
[44]
1998
Ostrousky et al., Jewish NQ02 372 T>c 14 4 14 40 50 78 3.5 0.04
[45]
2003 NQ 02 202 G>A 17 1 54 26 33 94 8.2 0.05
Lahdelma et al., Finnish HLA-A1, HLA-A28, HLA- 3 23 11 8 26% 21% 0.95 0.0013
[46]
2001 B16 8 18 1 18 50% 89% 8 0.027
6 16 2 17 51% 75% 3.2 0.027
Dettling et al., German Caucasians - non- HLA-Cw*7 20 11 30 47 81% 40% 2.85 0.02
[47]
2001 Jewish HLA-DPB*0401 23 8 40 33 80% 36% 2.37 0.03
HLA-DQB*0502 5 26 1 76 74% 83% 14.6 0.04
HLA-DRB1*0101 3 28 20 57 74% 9% 0.30 0.03
HLA-DRB3*0202 14 17 21 56 77% 40% 0.45 0.01
Dettling et al., German Caucasians - non- HLA-DRB5*0201 5 37 0 0 0% 100% 0.13 0.005
Jewish HLA-Cw7 29 13 33 42 76% 47% 2.84 0.035