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identified as personnel of the International Agency for Research on Cancer/World Health Organization, the
authors alone are responsible for the views expressed in this article and they do not necessarily represent the
decisions, policy or views of the International Agency for Research on Cancer/World Health Organization.

Ethical approval and consent to participate
All studies obtained informed consent from participants and were approved by their respective Institutional
Review Boards as listed. These are ATBC: (NCI Special Studies Institutional Review Board); BCCA: UBC
BC Cancer Agency Research Ethics Board; CPS-II: American Cancer Society; ELCCS: Northern and
Yorkshire Research Ethics Committee; ENGELA: IRB00003888 - Comite d’ Evaluation Ethique de l’Inserm
IRB # 1; EPIC: Imperial College London; EpiLymph: International Agency for Research on Cancer, HPFS:
Harvard School of Public Health (HSPH) Institutional Review Board; Iowa-Mayo SPORE: University of
Iowa Institutional Review Board; Italian GxE: Comitato Etico Azienda Ospedaliero Universitaria di Cagliari;
Mayo Clinic Case-Control: Mayo Clinic Institutional Review Board; Mayo GEC: Mayo Clinic Institutional
Review Board, #07-005788-03; MCCS: Cancer Council Victoria’s Human Research Ethics Committee; MD
Anderson: University of Texas MD Anderson Cancer Center Institutional Review Board; MSKCC:
Memorial Sloan-Kettering Cancer Center Institutional Review Board; NCI-SEER (NCI Special Studies
Institutional Review Board); NHS: Partners Human Research Committee, Brigham and Women’s Hospital,
NSW: NSW Cancer Council Ethics Committee; NYU-WHS: New York University School of Medicine
Institutional Review Board; PLCO: (NCI Special Studies Institutional Review Board); SCALE: Scientific
Ethics Committee for the Capital Region of Denmark; SCALE: Regional Ethical Review Board in Stockholm
(Section 4) IRB#5; UCSF1/UCSF2: University of California San Francisco Committee on Human Research;
UTAH: University of Utah; WHI: Fred Hutchinson Cancer Research Center; Yale: Human Investigation
Committee, Yale University School of Medicine.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2021.

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