Page 64 - Read Online

Page 440 Ciolino et al. J Transl Genet Genom 2022;6:429-42 https://dx.doi.org/10.20517/jtgg.2022.15

ASD, giving rise to the study of the mechanisms of generation of dynamic and static encephalopathy.

*A change is needed in the clinical approach for patients with an ASD diagnosis, where exhaustive clinical
exploration and proper diagnosis and treatment of CMP are conducted considering the complexity of ASD
(multi or hypermorbidity and heterogeneity). This is the first step to achieving health optimization,
introducing the use of non-medical therapies and optimizing their results.

DECLARATIONS
Authors’ contributions
Made substantial contributions to conception and design of the search of the published literature and
performed data analysis and interpretation: Ciolino A, Ferreira ML
Made substantial contribution to design of the study considering medical practice and interpretation of the
published literature and its potential application in real world contexts, supervision of whole manuscript:
Loyacono N

Availability of data and materials
Not applicable.

Financial support and sponsorship
None.

Conflicts of interest
Ferreira ML is the mother of a young man of 22 years, diagnosed in 2003 with Autism. From Jun 2015 to
Jun 2019 she was an ad-honorem Consultor in ASD to the Hospital de Clínicas José de San Martín (Buenos
Aires Argentina), directed by Drs. Loyacono N and Iermoli R (Res. Directorio CONICET 3070/2015). A
presentation for a potential agreement SANyTA (Director: Loyacono N)-CONICET (Consejo Nacional de
Investigaciones Científicas y Técnicas, from Argentina) is under development and will be presented for
consideration to CONICET next months 2022/2023. Ciolino A and Loyacono N declared that they have no
conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2022.

REFERENCES
1. Hoang N, Buchanan JA, Scherer SW. Heterogeneity in clinical sequencing tests marketed for autism spectrum disorders. NPJ Genom
Med 2018;3:27. DOI PubMed PMC
2. Dias CM, Walsh CA. Recent advances in understanding the genetic architecture of autism. Annu Rev Genomics Hum Genet
2020;21:289-304. DOI PubMed
3. Hertz-Picciotto I, Schmidt RJ, Krakowiak P. Understanding environmental contributions to autism: causal concepts and the state of
science. Autism Res 2018;11:554-86. DOI PubMed
4. Niesler B, Rappold GA. Emerging evidence for gene mutations driving both brain and gut dysfunction in autism spectrum disorder.
Mol Psychiatry 2021;26:1442-4. DOI PubMed PMC
5. Ghrálaigh F, McCarthy E, Murphy DN, Gallagher L, Lopez LM. Brief report: evaluating the diagnostic yield of commercial gene
panels in autism. J Autism Dev Disord 2022. DOI PubMed