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               REFERENCES
               1.   Liu JP. Molecular mechanisms of ageing and related diseases. Clin Exp Pharmacol Physiol 2014;41:445-58.
               2.   Goldsmith TC. Evolution of aging theories: why modern programmed aging concepts are transforming medical research. Biochemistry
                   (Mosc) 2016;81:1406-12.
               3.   Vaiserman AM. Aging-modulating treatments: from reductionism to a system-oriented perspective. Front Genet 2014;5:446.
               4.   Kyriazis M. Third phase science: defining a novel model of research into human ageing. Front Biosci (Landmark Ed) 2017;22:982-90.
               5.   Kyriazis M. Editorial: Re-thinking ageing: a cross-disciplinary perspective (a new era for ageing). Mech Ageing Dev 2017;163:1.
               6.   Cabrera D, Cabrera L. Systems thinking made simple: new hope for solving wicked problems. Ithaca, NY: Odyssean; 2015.
               7.   Asensio-Sánchez VM. Dracula was right: the elixir of youth could be the young blood. Arch Soc Esp Oftalmol 2015;90:453.
               8.   Elghblawi E. Platelet-rich plasma, the ultimate secret for youthful skin elixir and hair growth triggering. J Cosmet Dermatol 2018;17:423-
                   30.
               9.   Girgis CM. Vitamin D and muscle function in the elderly: the elixir of youth? Curr Opin Clin Nutr Metab Care 2014;17:546-50.
               10.  Andersen RE, Lim DA. An ingredient for the elixir of youth. Cell Res 2014;24:1381-2.
               11.  Check Hayden E. Anti-ageing pill pushed as bona fide drug. Nature 2015;522:265-6.
               12.  Bhullar KS, Hubbard BP. Lifespan and healthspan extension by resveratrol. Biochim Biophys Acta 2015;1852:1209-18.
               13.  Kumar S, Lombard DB. Finding Ponce de Leon’s Pill: challenges in screening for anti-aging molecules. F1000Res 2016;5:F1000 Faculty
                   Rev-406.
               14.  Cottin Y, Rochette L. A member of the TGF-β superfamily, GDF11: functions in the cardiac regeneration, perhaps an “elixir of youth?”.
                   Arch Cardiovasc Dis 2015;108:409-11.
               15.  Lucke JC, Diedrichs PC, Partridge B, Hall WD. Anticipating the anti-ageing pill. Lessons from the history of the oral contraceptive pill and
                   hormone replacement therapy. EMBO Rep 2009;10:108-13.
               16.  Wagner G. Towards a life prolonging pill? Small molecules with anti-ageing properties. Curr Drug Targets 2006;7:1531-7.
               17.  Blagosklonny MV. An anti-aging drug today: from senescence-promoting genes to anti-aging pill. Drug Discov Today 2007;12:218-24.
               18.  Zealley B, de Grey ADNJ. Commentary on some recent theses relevant to combating aging: February 2018. Rejuvenation Res 2018;21:70-
                   6.
               19.  Kyriazis M, Apostolides A. The fallacy of the longevity elixir: negligible senescence may be achieved, but not by using something physical.
                   Curr Aging Sci 2015;8:227-34.
               20.  Kyriazis M. The impracticality of biomedical rejuvenation therapies: translational and pharmacological barriers. Rejuvenation Res
                   2014;17:390-6.
               21.  Callahan CM, Foroud T, Saykin AJ, Shekhar A, Hendrie HC. Translational research on aging: clinical epidemiology as a bridge between the
                   sciences. Transl Res 2014;163:439-45.
               22.  Henney AM. The promise and challenge of personalized medicine: aging populations, complex diseases, and unmet medical need. Croat
                   Med J 2012;53:207-10.
               23.  de Magalhães JP. The scientific quest for lasting youth: prospects for curing aging. Rejuvenation Res 2014;17:458-67.
               24.  Mohler J, Najafi B, Fain M, Ramos KS. Precision medicine: a wider definition. J Am Geriatr Soc 2015;63:1971-2.
               25.  Reitz C. Toward precision medicine in Alzheimer’s disease. Ann Transl Med 2016;4:107.
               26.  Hampel H, O’Bryant SE, Castrillo JI, Ritchie C, Rojkova K, Broich K, Benda N, Nisticò R, Frank RA, Dubois B, Escott-Price V, Lista S.
                   Precision medicine - the golden gate for detection, treatment and prevention of Alzheimer’s disease. J Prev Alzheimers Dis 2016;3:243-59.
               27.  Zhu Y, Tchkonia T, Pirtskhalava T. The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 2015;14:644-58.
               28.  Roos CM, Zhang B, Palmer AK. Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.
                   Aging Cell 2016;15:973-7.
               29.  Zhu Y, Tchkonia T, Fuhrmann-Stroissnigg H. Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-
                   apoptotic factors. Aging Cell 2016;15:428-35.
               30.  Rahnasto-Rilla M, Tyni J, Huovinen M, Jarho E, Kulikowicz T, Ravichandran S, A Bohr V, Ferrucci L, Lahtela-Kakkonen M, Moaddel R.
                   Natural polyphenols as sirtuin 6 modulators. Sci Rep 2018;8:4163.
               31.  Kraig E, Linehan LA, Liang H, Romo TQ, Liu Q, Wu Y, Benavides AD, Curiel TJ, Javors MA, Musi N, Chiodo L, Koek W, Gelfond
                   JAL, Kellogg DL Jr. A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort:
                   Immunological, physical performance, and cognitive effects. Exp Gerontol 2018;105:53-69.
               32.  Ratho L, Pant A, Awasthi H. An antidiabetic polyherbal phytomedicine confers stress resistance and extends lifespan in Caenorhabditis
                   elegans. Biogerontology 2017;18:131-47.
               33.  Barzilai N, Crandall JP, Kritchevsky SB. Metformin as a tool to target aging. Cell Metab 2016;23:1060-5.
               34.  Strazhesko ID, Tkacheva ON, Akasheva DU. Atorvastatin therapy modulates telomerase activity in patients free of atherosclerotic
                   cardiovascular diseases. Front Pharmacol 2016;7:347.
               35.  Kyriazis M. Translating laboratory anti-aging biotechnology into applied clinical practice: problems and obstacles. World J Transl Med
                   2015;4:51-4.
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