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these reporter systems. Reviews from both teams are highly complementary and provide the reader with an
accurate, comprehensive picture of the progress made so far in this field.

Partial reactivation of the inactive X chromosome for therapeutic approaches has so far proven hard to
achieve and control. Nevertheless, it offers a new and exciting perspective for curing X-linked disorders.
Most importantly, I believe that the knowledge gained by studying the reversal of the Xi goes well beyond X
inactivation. Similar strategies could be used for treating a broad range of common illnesses, such as mental
health disorders linked to epigenetic gene-silencing, and some forms of cancer.

DECLARATIONS
Authors’ contributions
Cerase A contributed solely to this editorial.

Financial support and sponsorship
None.

Conflicts of interest
There are no conflicts of interest.

Patient consent
Not applicable.

Ethics approval
Not applicable.

Copyright
© The Author(s) 2018.

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